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Intracerebroventricular (i.c.v.) administration of choline, a precursor of acetylcholine (ACh) increased plasma prolactin levels in a time and dose-dependent manner in conscious rats. Pretreatment of rats with the cholinergic muscarinic antagonist, atropine (10 microg, i.c.v.), blocked the increase in plasma prolactin level. The increase was not influenced by pretreatment with the cholinergic nicotinic antagonist, mecamylamine (50 microg, i.c.v.). Pretreatment with hemicholinium-3 (HC-3; 20 microg, i.c.v.), a high affinity choline uptake inhibitor, attenuated the choline-induced increase of plasma prolactin levels. These results show that choline increases plasma prolactin levels by activating muscarinic receptors via presynaptic mechanisms.
M S Gürün, and
V Savci, and
I H Ulus, and
B K Kiran
February 2004,
Fundamental & clinical pharmacology,
M S Gürün, and
V Savci, and
I H Ulus, and
B K Kiran
January 1986,
NIDA research monograph,
M S Gürün, and
V Savci, and
I H Ulus, and
B K Kiran
April 1995,
American journal of hypertension,
M S Gürün, and
V Savci, and
I H Ulus, and
B K Kiran
May 1996,
Endocrinology,
M S Gürün, and
V Savci, and
I H Ulus, and
B K Kiran
January 1986,
Clinical and experimental hypertension. Part A, Theory and practice,
M S Gürün, and
V Savci, and
I H Ulus, and
B K Kiran
September 1985,
Neuropeptides,
M S Gürün, and
V Savci, and
I H Ulus, and
B K Kiran
September 1999,
Neuroendocrinology,
M S Gürün, and
V Savci, and
I H Ulus, and
B K Kiran
February 1985,
European journal of pharmacology,
M S Gürün, and
V Savci, and
I H Ulus, and
B K Kiran
July 1991,
Neuroscience letters,
M S Gürün, and
V Savci, and
I H Ulus, and
B K Kiran
March 1989,
European journal of pharmacology,
