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Penicillin-binding proteins and induction of AmpC beta-lactamase. 1997
C C Sanders, and
P A Bradford, and
A F Ehrhardt, and
K Bush, and
K D Young, and
T A Henderson, and
W E Sanders
Center for Research in Anti-Infectives and Biotechnology, Department of Medical Microbiology, Creighton University School of Medicine, Omaha, Nebraska 68178, USA.
In competition assays for radiolabeled penicillin, penicillin-binding proteins (PBPs) 4, 7a, and 7b showed very high affinities for strong inducers of AmpC beta-lactamase. Loss of PBP 4 resulted in diminished inducibility. This suggests that if PBPs are involved in induction of AmpC beta-lactamase, there is probably a redundancy in function among the different PBPs.
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