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A variety of extracellular signals are transduced across the cell membrane by the enzyme phosphoinositide-specific phospholipase C-beta (PLC-beta) coupled with guanine-nucleotide-binding G proteins. There are four isoenzymes of PLC-beta, beta1-beta4, but their functions in vivo are not known. Here we investigate the role of PLC-beta1 and PLC-beta4 in the brain by generating null mutations in mice: we found that PLCbeta1-/- mice developed epilepsy and PLCbeta4-/- mice showed ataxia. We determined the molecular basis of these phenotypes and show that PLC-beta1 is involved in signal transduction in the cerebral cortex and hippocampus by coupling predominantly to the muscarinic acetylcholine receptor, whereas PLC-beta4 works through the metabotropic glutamate receptor in the cerebellum, illustrating how PLC-beta isoenzymes are used to generate different functions in the brain.
D Kim, and
K S Jun, and
S B Lee, and
N G Kang, and
D S Min, and
Y H Kim, and
S H Ryu, and
P G Suh, and
H S Shin
January 1999,
Acta biochimica Polonica,
D Kim, and
K S Jun, and
S B Lee, and
N G Kang, and
D S Min, and
Y H Kim, and
S H Ryu, and
P G Suh, and
H S Shin
June 1997,
The Journal of biological chemistry,
D Kim, and
K S Jun, and
S B Lee, and
N G Kang, and
D S Min, and
Y H Kim, and
S H Ryu, and
P G Suh, and
H S Shin
June 2008,
BMB reports,
D Kim, and
K S Jun, and
S B Lee, and
N G Kang, and
D S Min, and
Y H Kim, and
S H Ryu, and
P G Suh, and
H S Shin
June 1992,
The Journal of biological chemistry,
D Kim, and
K S Jun, and
S B Lee, and
N G Kang, and
D S Min, and
Y H Kim, and
S H Ryu, and
P G Suh, and
H S Shin
December 1990,
Biochemical and biophysical research communications,
D Kim, and
K S Jun, and
S B Lee, and
N G Kang, and
D S Min, and
Y H Kim, and
S H Ryu, and
P G Suh, and
H S Shin
October 1987,
Molecular pharmacology,
D Kim, and
K S Jun, and
S B Lee, and
N G Kang, and
D S Min, and
Y H Kim, and
S H Ryu, and
P G Suh, and
H S Shin
January 1996,
Postepy biochemii,
D Kim, and
K S Jun, and
S B Lee, and
N G Kang, and
D S Min, and
Y H Kim, and
S H Ryu, and
P G Suh, and
H S Shin
January 1991,
Methods in enzymology,
D Kim, and
K S Jun, and
S B Lee, and
N G Kang, and
D S Min, and
Y H Kim, and
S H Ryu, and
P G Suh, and
H S Shin
January 1992,
Progress in growth factor research,
D Kim, and
K S Jun, and
S B Lee, and
N G Kang, and
D S Min, and
Y H Kim, and
S H Ryu, and
P G Suh, and
H S Shin
July 1994,
Naunyn-Schmiedeberg's archives of pharmacology,
