BIOMAT Database Logo BIOMAT Database Logo

The level of erythrocyte aldose reductase is associated with the severity of diabetic retinopathy. 1997

C Nishimura, and Y Hotta, and T Gui, and A Seko, and T Fujimaki, and T Ishikawa, and M Hayakawa, and A Kanai, and T Saito
Department of Pediatric Pharmacology, National Children's Medical Research Center, Tokyo, Japan. nchihiro@basic.kpu-m.ac.jp

To examine whether the level of erythrocyte aldose reductase is a risk factor for the severity of diabetic retinopathy, the enzyme level in 97 non-insulin-dependent diabetes mellitus (NIDDM) patients was measured by the two-site enzyme-linked immunosorbent assay. Based on the results of fundus photography and biomicroscopy, the severity of retinopathy was classified among NIDDM patients of more than 10 years. The level of erythrocyte aldose reductase was significantly higher in the patients with active proliferative retinopathy than in those with nonproliferative or quiescent proliferative retinopathy. Multivariate logistic regression analysis demonstrated that the level of erythrocyte aldose reductase was an independent risk factor for active proliferative retinopathy (odds ratio, 1.28; 95% confidence interval, 1.01-1.61). The results suggest that a high level of erythrocyte aldose reductase in NIDDM patients may affect the prognosis of diabetic retinopathy. Patients with high enzyme levels would need to be closely followed up in the management of the retinal complication.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D003924 Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY. Diabetes Mellitus, Adult-Onset,Diabetes Mellitus, Ketosis-Resistant,Diabetes Mellitus, Maturity-Onset,Diabetes Mellitus, Non-Insulin-Dependent,Diabetes Mellitus, Slow-Onset,Diabetes Mellitus, Stable,MODY,Maturity-Onset Diabetes Mellitus,NIDDM,Diabetes Mellitus, Non Insulin Dependent,Diabetes Mellitus, Noninsulin Dependent,Diabetes Mellitus, Noninsulin-Dependent,Diabetes Mellitus, Type II,Maturity-Onset Diabetes,Noninsulin-Dependent Diabetes Mellitus,Type 2 Diabetes,Type 2 Diabetes Mellitus,Adult-Onset Diabetes Mellitus,Diabetes Mellitus, Adult Onset,Diabetes Mellitus, Ketosis Resistant,Diabetes Mellitus, Maturity Onset,Diabetes Mellitus, Slow Onset,Diabetes, Maturity-Onset,Diabetes, Type 2,Ketosis-Resistant Diabetes Mellitus,Maturity Onset Diabetes,Maturity Onset Diabetes Mellitus,Non-Insulin-Dependent Diabetes Mellitus,Noninsulin Dependent Diabetes Mellitus,Slow-Onset Diabetes Mellitus,Stable Diabetes Mellitus
D003930 Diabetic Retinopathy Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION. Diabetic Retinopathies,Retinopathies, Diabetic,Retinopathy, Diabetic
D004912 Erythrocytes Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN. Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D005260 Female Females
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

C Nishimura, and Y Hotta, and T Gui, and A Seko, and T Fujimaki, and T Ishikawa, and M Hayakawa, and A Kanai, and T Saito
Correlation between erythrocyte aldose reductase level and human diabetic retinopathy.
December 2002, The British journal of ophthalmology,
C Nishimura, and Y Hotta, and T Gui, and A Seko, and T Fujimaki, and T Ishikawa, and M Hayakawa, and A Kanai, and T Saito
Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy.
March 2008, Molecular vision,
C Nishimura, and Y Hotta, and T Gui, and A Seko, and T Fujimaki, and T Ishikawa, and M Hayakawa, and A Kanai, and T Saito
An aldose reductase intragenic polymorphism associated with diabetic retinopathy.
November 1999, Diabetes research and clinical practice,
C Nishimura, and Y Hotta, and T Gui, and A Seko, and T Fujimaki, and T Ishikawa, and M Hayakawa, and A Kanai, and T Saito
Aldose reductase and diabetic retinopathy.
November 1992, Annals of ophthalmology,
C Nishimura, and Y Hotta, and T Gui, and A Seko, and T Fujimaki, and T Ishikawa, and M Hayakawa, and A Kanai, and T Saito
High levels of erythrocyte aldose reductase and diabetic retinopathy in NIDDM patients.
March 1994, Diabetologia,
C Nishimura, and Y Hotta, and T Gui, and A Seko, and T Fujimaki, and T Ishikawa, and M Hayakawa, and A Kanai, and T Saito
The level of erythrocyte aldose reductase: a risk factor for diabetic neuropathy?
June 1997, Diabetes research and clinical practice,
C Nishimura, and Y Hotta, and T Gui, and A Seko, and T Fujimaki, and T Ishikawa, and M Hayakawa, and A Kanai, and T Saito
Aldose reductase / polyol inhibitors for diabetic retinopathy.
March 2011, Current pharmaceutical biotechnology,
C Nishimura, and Y Hotta, and T Gui, and A Seko, and T Fujimaki, and T Ishikawa, and M Hayakawa, and A Kanai, and T Saito
Association of aldose reductase gene (AKR1B1) polymorphism with diabetic retinopathy.
November 2016, Diabetes research and clinical practice,
C Nishimura, and Y Hotta, and T Gui, and A Seko, and T Fujimaki, and T Ishikawa, and M Hayakawa, and A Kanai, and T Saito
Aldose reductase gene polymorphisms and diabetic retinopathy susceptibility.
August 2010, Diabetes care,
C Nishimura, and Y Hotta, and T Gui, and A Seko, and T Fujimaki, and T Ishikawa, and M Hayakawa, and A Kanai, and T Saito
Erythrocyte aldose reductase correlates with erectile dysfunction in diabetic patients.
August 2002, International journal of impotence research,
Copied contents to your clipboard!