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The potential for myocardial protection during cardiac operation was evaluated by adding Dibutyryl cyclic AMP (DBcAMP) to the crystalloid cardioplegic solutions. We have compared the cold crystalloid cardioplegia with DBcAMP (Group D n = 15) and without DBcAMP (Group n = 20) in patients undergoing cardiac operation. In hemodynamics, both groups were no difference before and after operation. CPK and CPK-MB was significantly (p < 0.01) high level after cardiopulmonary bypass (CPB) in group C. Myoglobin was also high value after CBP in group C, but not significant. Myocardial oxygen extraction rate and coronary blood PCO2 release were similar change in both groups. Insulin/glucose ratio was high level during and after CBP in group D. Myocardial lactate/pyruvate ratio was very high level after CBP in group C without significant difference. We consider that the cardioplegic solution with DBcAMP is effectual for the myocardial metabolism and preservation of myocardial damage during cardiac arrest.
Y Ishikura, and
S Odagiri, and
A Shimazu, and
H Tokunaga, and
M Shimokawaji, and
H Yoshimatsu
February 1994,
The Journal of cardiovascular surgery,
Y Ishikura, and
S Odagiri, and
A Shimazu, and
H Tokunaga, and
M Shimokawaji, and
H Yoshimatsu
February 1988,
The Journal of thoracic and cardiovascular surgery,
Y Ishikura, and
S Odagiri, and
A Shimazu, and
H Tokunaga, and
M Shimokawaji, and
H Yoshimatsu
August 1986,
The Annals of thoracic surgery,
Y Ishikura, and
S Odagiri, and
A Shimazu, and
H Tokunaga, and
M Shimokawaji, and
H Yoshimatsu
February 1996,
The Annals of thoracic surgery,
Y Ishikura, and
S Odagiri, and
A Shimazu, and
H Tokunaga, and
M Shimokawaji, and
H Yoshimatsu
April 1981,
The Journal of surgical research,
Y Ishikura, and
S Odagiri, and
A Shimazu, and
H Tokunaga, and
M Shimokawaji, and
H Yoshimatsu
February 1987,
The Journal of thoracic and cardiovascular surgery,
Y Ishikura, and
S Odagiri, and
A Shimazu, and
H Tokunaga, and
M Shimokawaji, and
H Yoshimatsu
January 2011,
Transplantation proceedings,
Y Ishikura, and
S Odagiri, and
A Shimazu, and
H Tokunaga, and
M Shimokawaji, and
H Yoshimatsu
May 1984,
Canadian journal of surgery. Journal canadien de chirurgie,
Y Ishikura, and
S Odagiri, and
A Shimazu, and
H Tokunaga, and
M Shimokawaji, and
H Yoshimatsu
June 1999,
The Thoracic and cardiovascular surgeon,
Y Ishikura, and
S Odagiri, and
A Shimazu, and
H Tokunaga, and
M Shimokawaji, and
H Yoshimatsu
May 1983,
The Journal of thoracic and cardiovascular surgery,
