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31 families with at least two psoriatic members, including sometimes three generations (4 families) have been studied looking for HL-A markers. They include 80 affected (45 females, 35 males) and 75 healthy persons. BW 17 has been found present in 58 p. 100 of the unrelated patients, versus 7 p. 100 only in the normal population (p less than 10-9). Relative risk (R.R.) for the people bearing BW 17 is 38.34. Increase of B 13 is slight and non significant. BW 16, BW 37, BW 27 are within normal range. B 12 (R.R. :0.36) seems to have a protecting effect. B 8, B 14 are also decreased. Study of way of genetic transmission favours existence of a dominant gene of susceptibility frequently associated with BW 17 and particularly with haplotype A 1, BW 17. But other genetic or environmental factors may also play a role.
J Civatte, and
C Lazarovici, and
P Ganas, and
S Léon, and
J Hors, and
L Contu, and
J Dausset
January 1979,
Sangre,
J Civatte, and
C Lazarovici, and
P Ganas, and
S Léon, and
J Hors, and
L Contu, and
J Dausset
March 1974,
Deutsche medizinische Wochenschrift (1946),
J Civatte, and
C Lazarovici, and
P Ganas, and
S Léon, and
J Hors, and
L Contu, and
J Dausset
January 1976,
Annales d'endocrinologie,
J Civatte, and
C Lazarovici, and
P Ganas, and
S Léon, and
J Hors, and
L Contu, and
J Dausset
March 1975,
Casopis lekaru ceskych,
J Civatte, and
C Lazarovici, and
P Ganas, and
S Léon, and
J Hors, and
L Contu, and
J Dausset
January 1974,
Zeitschrift fur Rechtsmedizin. Journal of legal medicine,
J Civatte, and
C Lazarovici, and
P Ganas, and
S Léon, and
J Hors, and
L Contu, and
J Dausset
November 1975,
Bratislavske lekarske listy,
J Civatte, and
C Lazarovici, and
P Ganas, and
S Léon, and
J Hors, and
L Contu, and
J Dausset
January 1974,
Przeglad lekarski,
J Civatte, and
C Lazarovici, and
P Ganas, and
S Léon, and
J Hors, and
L Contu, and
J Dausset
May 1974,
Zeitschrift fur Rechtsmedizin. Journal of legal medicine,
J Civatte, and
C Lazarovici, and
P Ganas, and
S Léon, and
J Hors, and
L Contu, and
J Dausset
January 1980,
Sangre,
J Civatte, and
C Lazarovici, and
P Ganas, and
S Léon, and
J Hors, and
L Contu, and
J Dausset
January 1974,
Bratislavske lekarske listy,
