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Of the epileptic patients who were treated for > or = 5 years until the end of 1990 and had more than four seizures in 1990, 63 patients had been treated without interruption until the end of 1995. We analyzed their clinical courses from 1990 to 1995 prospectively. More than half the subjects were diagnosed with temporal lobe epilepsy. Twenty cases had presumed etiology, and 32 had neuropsychiatric complications. Of the subjects whose seizures were not controlled with conventional antiepileptic drugs (AED), 11 cases demonstrated significant improvement when new AED; that is, lamotrigine, vigabatrin, clobazam, topiramate, tiagabine or CGP33101 were added. However, 10 patients did not respond to new AED. Presumed etiology, neuropsychiatric complications, multiple epileptic foci in EEG and abnormalities on head CT or MRI were characteristics of the patients whose seizures were resistant to new AED.
K Wada, and
K Kiryu, and
Y Kawata, and
T Chiba, and
K Mizuno, and
M Okada, and
H Tasaki, and
Y Fukushima, and
F Saito, and
S Kaneko
June 2013,
Epilepsia,
K Wada, and
K Kiryu, and
Y Kawata, and
T Chiba, and
K Mizuno, and
M Okada, and
H Tasaki, and
Y Fukushima, and
F Saito, and
S Kaneko
September 1987,
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K Wada, and
K Kiryu, and
Y Kawata, and
T Chiba, and
K Mizuno, and
M Okada, and
H Tasaki, and
Y Fukushima, and
F Saito, and
S Kaneko
January 1998,
Neurology India,
K Wada, and
K Kiryu, and
Y Kawata, and
T Chiba, and
K Mizuno, and
M Okada, and
H Tasaki, and
Y Fukushima, and
F Saito, and
S Kaneko
June 2001,
Neurology,
K Wada, and
K Kiryu, and
Y Kawata, and
T Chiba, and
K Mizuno, and
M Okada, and
H Tasaki, and
Y Fukushima, and
F Saito, and
S Kaneko
July 2002,
Neurology,
K Wada, and
K Kiryu, and
Y Kawata, and
T Chiba, and
K Mizuno, and
M Okada, and
H Tasaki, and
Y Fukushima, and
F Saito, and
S Kaneko
December 2008,
The Pediatric infectious disease journal,
K Wada, and
K Kiryu, and
Y Kawata, and
T Chiba, and
K Mizuno, and
M Okada, and
H Tasaki, and
Y Fukushima, and
F Saito, and
S Kaneko
April 2009,
International journal of cardiology,
K Wada, and
K Kiryu, and
Y Kawata, and
T Chiba, and
K Mizuno, and
M Okada, and
H Tasaki, and
Y Fukushima, and
F Saito, and
S Kaneko
September 1987,
The Japanese journal of psychiatry and neurology,
K Wada, and
K Kiryu, and
Y Kawata, and
T Chiba, and
K Mizuno, and
M Okada, and
H Tasaki, and
Y Fukushima, and
F Saito, and
S Kaneko
February 1995,
Epilepsy research,
K Wada, and
K Kiryu, and
Y Kawata, and
T Chiba, and
K Mizuno, and
M Okada, and
H Tasaki, and
Y Fukushima, and
F Saito, and
S Kaneko
March 1998,
Epilepsia,
