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The mechanism of action of flunarizine (FZ) and cinnarizine (CZ) on the CNS is not fully understood. Computer analysis of saccadic eye movements (SEM) provides a sensitive and objective method for evaluating drug effect on the function of specific brain structures. This study aimed to assess the effect of a single oral dose of FZ (20 mg) and CZ (150 mg) on CNS function by means of computer analysis of SEM. Ten healthy volunteers were studied according to a double-blind, cross-over, placebo-controlled design. Peak saccadic velocity (PSV), which is related to the function of a specific group of burst neurons located in the brain stem, was significantly reduced by FZ. No significant effect of FZ on saccade accuracy (SA) and saccade latency (SL) was found. CZ did not produce significant effects on SEM, but a trend to decrease PSV. The possibility that a FZ central effect may be related to a stabilizing action on burst activity of neurons is discussed.
G Casucci, and
A Di Costanzo, and
R Riva, and
F Albani, and
V Bonavita, and
G Tedeschi
January 1989,
Movement disorders : official journal of the Movement Disorder Society,
G Casucci, and
A Di Costanzo, and
R Riva, and
F Albani, and
V Bonavita, and
G Tedeschi
January 1978,
ORL; journal for oto-rhino-laryngology and its related specialties,
G Casucci, and
A Di Costanzo, and
R Riva, and
F Albani, and
V Bonavita, and
G Tedeschi
June 1999,
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology,
G Casucci, and
A Di Costanzo, and
R Riva, and
F Albani, and
V Bonavita, and
G Tedeschi
January 1990,
Brain research,
G Casucci, and
A Di Costanzo, and
R Riva, and
F Albani, and
V Bonavita, and
G Tedeschi
January 2007,
Physiological research,
G Casucci, and
A Di Costanzo, and
R Riva, and
F Albani, and
V Bonavita, and
G Tedeschi
August 1967,
Journal of the Optical Society of America,
G Casucci, and
A Di Costanzo, and
R Riva, and
F Albani, and
V Bonavita, and
G Tedeschi
May 1987,
Neurology,
G Casucci, and
A Di Costanzo, and
R Riva, and
F Albani, and
V Bonavita, and
G Tedeschi
March 2020,
Cephalalgia : an international journal of headache,
G Casucci, and
A Di Costanzo, and
R Riva, and
F Albani, and
V Bonavita, and
G Tedeschi
September 2004,
Arquivos de neuro-psiquiatria,
G Casucci, and
A Di Costanzo, and
R Riva, and
F Albani, and
V Bonavita, and
G Tedeschi
September 1979,
Nippon Ganka Gakkai zasshi,
