-transparent.png){kind=logo}
The efficiency of 5-iodo-5'-amino-2'5'-dideoxyuridine (AIU) in the therapy of experimental herpes keratitis in rabbits has been examined. Virus infections were established bilaterally in 40 animals using herpes simplex, type 1 (NIH strain 11124). Twenty-four hours after infection the rabbits were divided into five matched groups of eight and each group was treated, double-blind, with topical drugs at four-hour intervals for a total of 72 hours. The solutions instilled were: (1) saline; (2) IdUrd, 1 mg. per milliliter; (3) AIU, 1 mg. per milliliter; (4) AIU, 4 mg. per milliter; and (5) AIU, 8 mg. per milliliter. Each eye was examined daily for 12 days and graded independently by two ophthalmologists. Although IdUrd and AIU (8 mg. per milliliter) were effective therapeutically, IdUrd had a greater effect. The AIU at 1 and 4 mg. per milliliter were less active, but showed more rapid healing than the saline control. Viral recovery studies are consistent with the clinical observations. A second independent experiment, similar to that described above, gave essentially identical results. Although less potent than IdUrd, AIU does provide effective therapy for herpes keratitis.
D M Albert, and
M Lahav, and
P N Bhatt, and
T W Reid, and
R E Ward, and
R C Cykiert, and
T S Lin, and
D C Ward, and
W H Prusoff
October 1977,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
D M Albert, and
M Lahav, and
P N Bhatt, and
T W Reid, and
R E Ward, and
R C Cykiert, and
T S Lin, and
D C Ward, and
W H Prusoff
October 1979,
The Journal of biological chemistry,
D M Albert, and
M Lahav, and
P N Bhatt, and
T W Reid, and
R E Ward, and
R C Cykiert, and
T S Lin, and
D C Ward, and
W H Prusoff
May 1984,
Molecular pharmacology,
D M Albert, and
M Lahav, and
P N Bhatt, and
T W Reid, and
R E Ward, and
R C Cykiert, and
T S Lin, and
D C Ward, and
W H Prusoff
August 1976,
The Journal of biological chemistry,
D M Albert, and
M Lahav, and
P N Bhatt, and
T W Reid, and
R E Ward, and
R C Cykiert, and
T S Lin, and
D C Ward, and
W H Prusoff
October 1980,
Cancer research,
D M Albert, and
M Lahav, and
P N Bhatt, and
T W Reid, and
R E Ward, and
R C Cykiert, and
T S Lin, and
D C Ward, and
W H Prusoff
January 1979,
Pharmacology & therapeutics,
D M Albert, and
M Lahav, and
P N Bhatt, and
T W Reid, and
R E Ward, and
R C Cykiert, and
T S Lin, and
D C Ward, and
W H Prusoff
August 1976,
The Journal of biological chemistry,
D M Albert, and
M Lahav, and
P N Bhatt, and
T W Reid, and
R E Ward, and
R C Cykiert, and
T S Lin, and
D C Ward, and
W H Prusoff
July 1979,
Antimicrobial agents and chemotherapy,
D M Albert, and
M Lahav, and
P N Bhatt, and
T W Reid, and
R E Ward, and
R C Cykiert, and
T S Lin, and
D C Ward, and
W H Prusoff
February 1962,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
D M Albert, and
M Lahav, and
P N Bhatt, and
T W Reid, and
R E Ward, and
R C Cykiert, and
T S Lin, and
D C Ward, and
W H Prusoff
February 1980,
Biochimica et biophysica acta,
