Biomaterial Database

Ewing sarcoma metastatic to the iris. 1997

K Gündüz, and J A Shields, and C L Shields, and P De Potter, and M J Wayner

Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA 19107, USA.

OBJECTIVE To report a case of Ewing sarcoma metastatic to the iris. METHODS A 19-year-old woman with metastatic Ewing sarcoma of the femur developed a diffuse, fluffy iris mass with a pseudohypopyon in the left eye. A fine-needle aspiration biopsy confirmed iris metastasis, and external beam radiotherapy was given to the affected eye. RESULTS The iris mass responded initially to external beam radiotherapy and ongoing chemotherapy with vincristine, cyclophosphamide, doxorubicin, etoposide, and ifosfamide but recurred 5 months later. Subsequent radiotherapy with an iodine 125 plaque achieved further resolution of the iris tumor. CONCLUSIONS Ewing sarcoma can rarely metastasize to the iris. The diagnosis can be confirmed by fine-needle aspiration biopsy. Plaque radiotherapy is a therapeutic alternative.

UI	MeSH Term	Description	Entries
D007457	Iodine Radioisotopes	Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.	Radioisotopes, Iodine
D009364	Neoplasm Recurrence, Local	The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.	Local Neoplasm Recurrence,Local Neoplasm Recurrences,Locoregional Neoplasm Recurrence,Neoplasm Recurrence, Locoregional,Neoplasm Recurrences, Local,Recurrence, Local Neoplasm,Recurrence, Locoregional Neoplasm,Recurrences, Local Neoplasm,Locoregional Neoplasm Recurrences,Neoplasm Recurrences, Locoregional,Recurrences, Locoregional Neoplasm
D001859	Bone Neoplasms	Tumors or cancer located in bone tissue or specific BONES.	Bone Cancer,Cancer of Bone,Cancer of the Bone,Neoplasms, Bone,Bone Neoplasm,Neoplasm, Bone
D001918	Brachytherapy	A collective term for interstitial, intracavity, and surface radiotherapy. It uses small sealed or partly-sealed sources that may be placed on or near the body surface or within a natural body cavity or implanted directly into the tissues.	Curietherapy,Implant Radiotherapy,Plaque Therapy, Radioisotope,Radioisotope Brachytherapy,Radiotherapy, Interstitial,Radiotherapy, Intracavity,Radiotherapy, Surface,Brachytherapy, Radioisotope,Interstitial Radiotherapy,Intracavity Radiotherapy,Radioisotope Plaque Therapy,Radiotherapy, Implant,Surface Radiotherapy,Therapy, Radioisotope Plaque
D003131	Combined Modality Therapy	The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.	Multimodal Treatment,Therapy, Combined Modality,Combined Modality Therapies,Modality Therapies, Combined,Modality Therapy, Combined,Multimodal Treatments,Therapies, Combined Modality,Treatment, Multimodal,Treatments, Multimodal
D005260	Female		Females
D005269	Femur	The longest and largest bone of the skeleton, it is situated between the hip and the knee.	Trochanter,Greater Trochanter,Lesser Trochanter,Femurs,Greater Trochanters,Lesser Trochanters,Trochanter, Greater,Trochanter, Lesser,Trochanters,Trochanters, Greater,Trochanters, Lesser
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D012512	Sarcoma, Ewing	A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females.	Ewing's Tumor,Sarcoma, Ewing's,Ewing Sarcoma,Ewing Tumor,Ewing's Sarcoma,Ewings Sarcoma,Ewings Tumor,Sarcoma, Ewings,Tumor, Ewing,Tumor, Ewing's

Related Publications

K Gündüz, and J A Shields, and C L Shields, and P De Potter, and M J Wayner

Primary Ewing sarcoma of the iris.

January 2014, Lancet (London, England),

K Gündüz, and J A Shields, and C L Shields, and P De Potter, and M J Wayner

Spinal Ewing Sarcoma Metastatic to Bilateral Orbits.

January 2018, Ophthalmic plastic and reconstructive surgery,

K Gündüz, and J A Shields, and C L Shields, and P De Potter, and M J Wayner

Radiotherapy in metastatic ewing sarcoma.

June 2013, American journal of clinical oncology,

K Gündüz, and J A Shields, and C L Shields, and P De Potter, and M J Wayner

Metastatic Ewing sarcoma to the heart simulating adriamycin cardiotoxicity.

January 1978, Medical and pediatric oncology,

K Gündüz, and J A Shields, and C L Shields, and P De Potter, and M J Wayner

Radiotherapy of non-metastatic ewing sarcoma.

January 1985, Journal of cancer research and clinical oncology,

K Gündüz, and J A Shields, and C L Shields, and P De Potter, and M J Wayner

Metastatic Ewing sarcoma masquerading as olfactory neuroblastoma.

October 2006, European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery,

K Gündüz, and J A Shields, and C L Shields, and P De Potter, and M J Wayner

ERBB4 confers metastatic capacity in Ewing sarcoma.

July 2013, EMBO molecular medicine,

K Gündüz, and J A Shields, and C L Shields, and P De Potter, and M J Wayner

Palliative radiation therapy for metastatic Ewing sarcoma.

April 2006, Cancer,

K Gündüz, and J A Shields, and C L Shields, and P De Potter, and M J Wayner

Pulmonary coccidiomycosis masquerading as refractory metastatic Ewing sarcoma.

January 2014, Journal of pediatric hematology/oncology,

K Gündüz, and J A Shields, and C L Shields, and P De Potter, and M J Wayner

Bone Marrow Involvement in Metastatic Pediatric Ewing Sarcoma.

August 2017, Journal of the College of Physicians and Surgeons--Pakistan : JCPSP,