BIOMAT Database Logo BIOMAT Database Logo

The intrinsic coagulation/kinin-forming cascade: assembly in plasma and cell surfaces in inflammation. 1997

A P Kaplan, and K Joseph, and Y Shibayama, and S Reddigari, and B Ghebrehiwet, and M Silverberg
Department of Medicine, State University of New York, Stony Brook 11794-8161, USA.

UI MeSH Term Description Entries
D006967 Hypersensitivity Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen. Allergy,Allergic Reaction,Allergic Reactions,Allergies,Hypersensitivities,Reaction, Allergic,Reactions, Allergic
D007249 Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D007704 Kininogens Endogenous peptides present in most body fluids. Certain enzymes convert them to active KININS which are involved in inflammation, blood clotting, complement reactions, etc. Kininogens belong to the cystatin superfamily. They are cysteine proteinase inhibitors. HIGH-MOLECULAR-WEIGHT KININOGEN; (HMWK); is split by plasma kallikrein to produce BRADYKININ. LOW-MOLECULAR-WEIGHT KININOGEN; (LMWK); is split by tissue kallikrein to produce KALLIDIN. Cystatins, Kininogen,Kininogen,Prekinins,Prokinins,T-Kininogen,Thiostatin,Kininogen Cystatins,T Kininogen
D007705 Kinins A generic term used to describe a group of polypeptides with related chemical structures and pharmacological properties that are widely distributed in nature. These peptides are AUTACOIDS that act locally to produce pain, vasodilatation, increased vascular permeability, and the synthesis of prostaglandins. Thus, they comprise a subset of the large number of mediators that contribute to the inflammatory response. (From Goodman and Gilman's The Pharmacologic Basis of Therapeutics, 8th ed, p588) Kinin
D008562 Membrane Glycoproteins Glycoproteins found on the membrane or surface of cells. Cell Surface Glycoproteins,Surface Glycoproteins,Cell Surface Glycoprotein,Membrane Glycoprotein,Surface Glycoprotein,Glycoprotein, Cell Surface,Glycoprotein, Membrane,Glycoprotein, Surface,Glycoproteins, Cell Surface,Glycoproteins, Membrane,Glycoproteins, Surface,Surface Glycoprotein, Cell,Surface Glycoproteins, Cell
D008958 Models, Molecular Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures. Molecular Models,Model, Molecular,Molecular Model
D010958 Plasminogen Precursor of plasmin (FIBRINOLYSIN). It is a single-chain beta-globulin of molecular weight 80-90,000 found mostly in association with fibrinogen in plasma; plasminogen activators change it to fibrinolysin. It is used in wound debriding and has been investigated as a thrombolytic agent. Profibrinolysin,Glu-Plasminogen,Glutamic Acid 1-Plasminogen,Glutamyl Plasminogen,1-Plasminogen, Glutamic Acid,Glu Plasminogen,Glutamic Acid 1 Plasminogen,Plasminogen, Glutamyl
D011288 Prekallikrein A plasma protein which is the precursor of kallikrein. Plasma that is deficient in prekallikrein has been found to be abnormal in thromboplastin formation, kinin generation, evolution of a permeability globulin, and plasmin formation. The absence of prekallikrein in plasma leads to Fletcher factor deficiency, a congenital disease. Fletcher Factor,Plasma Prokallikrein,Kallikreinogen,Plasma Prokallikrein A,Factor, Fletcher,Prokallikrein A, Plasma,Prokallikrein, Plasma
D011487 Protein Conformation The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain). Conformation, Protein,Conformations, Protein,Protein Conformations
D011951 Receptors, Complement Molecules on the surface of some B-lymphocytes and macrophages, that recognize and combine with the C3b, C3d, C1q, and C4b components of complement. Complement Receptors,Complement Receptor,Complement Receptor Type 1,Receptor, Complement

Related Publications

A P Kaplan, and K Joseph, and Y Shibayama, and S Reddigari, and B Ghebrehiwet, and M Silverberg
Assembly of the human plasma kinin-forming cascade along the surface of vascular endothelial cells.
January 1995, International archives of allergy and immunology,
A P Kaplan, and K Joseph, and Y Shibayama, and S Reddigari, and B Ghebrehiwet, and M Silverberg
The intrinsic coagulation-kinin pathway, complement cascades, plasma renin-angiotensin system, and their interrelationships.
September 1981, Critical reviews in immunology,
A P Kaplan, and K Joseph, and Y Shibayama, and S Reddigari, and B Ghebrehiwet, and M Silverberg
The plasma kinin-forming system in labour.
October 1973, Clinical science and molecular medicine,
A P Kaplan, and K Joseph, and Y Shibayama, and S Reddigari, and B Ghebrehiwet, and M Silverberg
Observations on intrinsic kinin-forming factors in human plasma: the effect of acid, acetone, chloroform, heat and euglobulin separation on kinin formation.
May 1963, The Journal of physiology,
A P Kaplan, and K Joseph, and Y Shibayama, and S Reddigari, and B Ghebrehiwet, and M Silverberg
[Coagulation-fibrinolysis and kinin-forming systems in toxemia of pregnancy].
January 1988, Nihon Sanka Fujinka Gakkai zasshi,
A P Kaplan, and K Joseph, and Y Shibayama, and S Reddigari, and B Ghebrehiwet, and M Silverberg
Coagulation-fibrinolytic and kinin-forming systems in toxemia of pregnancy.
January 1988, Gynecologic and obstetric investigation,
A P Kaplan, and K Joseph, and Y Shibayama, and S Reddigari, and B Ghebrehiwet, and M Silverberg
Plasma-kinin-forming enzyme in human skin: extraction and column chromatographic separation of plasma-kinin-forming enzyme and its inhibitor.
January 1978, Acta dermato-venereologica,
A P Kaplan, and K Joseph, and Y Shibayama, and S Reddigari, and B Ghebrehiwet, and M Silverberg
The coagulation-kinin pathway of human plasma.
July 1987, Blood,
A P Kaplan, and K Joseph, and Y Shibayama, and S Reddigari, and B Ghebrehiwet, and M Silverberg
Contact activation of the plasma coagulation cascade. II. Protein adsorption to procoagulant surfaces.
August 1995, Journal of biomedical materials research,
A P Kaplan, and K Joseph, and Y Shibayama, and S Reddigari, and B Ghebrehiwet, and M Silverberg
Plasma-kinin-forming enzymes in body fluids and tissues.
October 1959, The Journal of physiology,
Copied contents to your clipboard!