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OBJECTIVE To investigate the sera of patients with oral squamous cell carcinoma (OSCC) for the existence of p53 auto-antibodies. METHODS The sera of thirty-nine OSCC-patients were investigated. All samples were from untreated patients with no history of another neoplastic disease. The sera of nine healthy subjects served as controls. RESULTS P53 auto-antibodies were not detected both in all healthy subjects and in 20.6% OSCC-patients with their disease at an advanced stage. We prove that the extinction rates for p53 auto-antibodies in OSCC are very weak in the majority of investigated sera (50%) and are not related to tumour stage. CONCLUSIONS It is unlikely that p53 auto-antibodies can serve as a prognostic marker of OSCC.
R E Friedrich, and
S Bartel-Friedrich, and
K Plambeck, and
M Bahlo, and
R Klapdor
October 1998,
International journal of cancer,
R E Friedrich, and
S Bartel-Friedrich, and
K Plambeck, and
M Bahlo, and
R Klapdor
January 1975,
IARC scientific publications,
R E Friedrich, and
S Bartel-Friedrich, and
K Plambeck, and
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R Klapdor
September 1997,
International journal of oncology,
R E Friedrich, and
S Bartel-Friedrich, and
K Plambeck, and
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R E Friedrich, and
S Bartel-Friedrich, and
K Plambeck, and
M Bahlo, and
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May 2002,
Laryngo- rhino- otologie,
R E Friedrich, and
S Bartel-Friedrich, and
K Plambeck, and
M Bahlo, and
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July 2008,
Odontology,
R E Friedrich, and
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September 2000,
The Journal of pathology,
R E Friedrich, and
S Bartel-Friedrich, and
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September 1996,
Journal of the National Cancer Institute,
R E Friedrich, and
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July 2015,
Acta medica Iranica,
R E Friedrich, and
S Bartel-Friedrich, and
K Plambeck, and
M Bahlo, and
R Klapdor
January 2016,
Asian Pacific journal of cancer prevention : APJCP,
