-transparent.png){kind=logo}
Novel benzophenone derivatives were synthesized and screened for cytotoxic and antitumor activity. Friedel-Crafts condensation was employed to construct the benzophenone skeleton. Among the compounds synthesized, morpholino and thiomorpholino benzophenones 3a-d exhibited potent cytotoxic activity against P388 murine leukemia and PC-6 human lung carcinoma cells in vitro, and compounds 3a, 3c, and 3j, when administered intraperitoneally, showed significant antitumor activity against the malignant ascites caused by intraperitoneal inoculation of P388 cells in mice.
Related Publications
E Kumazawa, and
K Hirotani, and
S C Burford, and
K Kawagoe, and
T Miwa, and
I Mitsui, and
A Ejima
February 2022,
Journal of Asian natural products research,
E Kumazawa, and
K Hirotani, and
S C Burford, and
K Kawagoe, and
T Miwa, and
I Mitsui, and
A Ejima
April 2013,
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
E Kumazawa, and
K Hirotani, and
S C Burford, and
K Kawagoe, and
T Miwa, and
I Mitsui, and
A Ejima
January 2019,
International journal of nanomedicine,
E Kumazawa, and
K Hirotani, and
S C Burford, and
K Kawagoe, and
T Miwa, and
I Mitsui, and
A Ejima
September 2017,
Molecules (Basel, Switzerland),
E Kumazawa, and
K Hirotani, and
S C Burford, and
K Kawagoe, and
T Miwa, and
I Mitsui, and
A Ejima
June 2019,
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
E Kumazawa, and
K Hirotani, and
S C Burford, and
K Kawagoe, and
T Miwa, and
I Mitsui, and
A Ejima
January 2013,
European journal of medicinal chemistry,
E Kumazawa, and
K Hirotani, and
S C Burford, and
K Kawagoe, and
T Miwa, and
I Mitsui, and
A Ejima
February 2012,
Investigational new drugs,
E Kumazawa, and
K Hirotani, and
S C Burford, and
K Kawagoe, and
T Miwa, and
I Mitsui, and
A Ejima
April 1999,
Journal of medicinal chemistry,
E Kumazawa, and
K Hirotani, and
S C Burford, and
K Kawagoe, and
T Miwa, and
I Mitsui, and
A Ejima
July 2021,
Journal of Asian natural products research,
E Kumazawa, and
K Hirotani, and
S C Burford, and
K Kawagoe, and
T Miwa, and
I Mitsui, and
A Ejima
August 2012,
Bioorganic & medicinal chemistry letters,
