Biomaterial Database

Sympathetic influence on ventricular compliance. 1976

B Coleman, and M C Worthen, and D M McCanon, and J E Kallal, and A A Luisada

Intracisternal injections of veratrine in the anesthetized dog were used to study the effects of extreme sympathetic stimulation on left ventricular diastolic compliance. The results obtained were compared with those seen during volume expansion with whole blood, and after removal of both stellate ganglia. The injection of veratrine into the cisterna magna caused an increase in left ventricular end-diastolic pressure (LVEDP) which was considerably larger than that which occurred in left ventricular end-diastolic circumferential (LVEDC) segment length suggesting a reduction in diastolic compliance. There were also increases in left ventricular systolic pressure (LVSP) as well as its first derivative (LV dp/dt). Bilateral stellectomy during the veratrine response abruptly reduced LVEDP with a lesser decrease in LVEDC. Thus, the left ventricular compliance change was reversed. Both LVSP and LV dp/dt were decreased by stellectomy but remained above control levels. During transfusion, the pressure-length curve of the ventricle was located downward and to the right in comparison with the curve observed with intracisternal veratrine.

UI	MeSH Term	Description	Entries
D007276	Injections, Intraventricular	Injections into the cerebral ventricles.	Intraventricular Injections,Injection, Intraventricular,Intraventricular Injection
D009200	Myocardial Contraction	Contractile activity of the MYOCARDIUM.	Heart Contractility,Inotropism, Cardiac,Cardiac Inotropism,Cardiac Inotropisms,Contractilities, Heart,Contractility, Heart,Contraction, Myocardial,Contractions, Myocardial,Heart Contractilities,Inotropisms, Cardiac,Myocardial Contractions
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D001803	Blood Transfusion	The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)	Blood Transfusions,Transfusion, Blood,Transfusions, Blood
D002306	Cardiac Volume	The volume of the HEART, usually relating to the volume of BLOOD contained within it at various periods of the cardiac cycle. The amount of blood ejected from a ventricle at each beat is STROKE VOLUME.	Heart Volume,Cardiac Volumes,Heart Volumes,Volume, Cardiac,Volume, Heart,Volumes, Cardiac,Volumes, Heart
D003187	Compliance	Distensibility measure of a chamber such as the lungs (LUNG COMPLIANCE) or bladder. Compliance is expressed as a change in volume per unit change in pressure.
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D006321	Heart	The hollow, muscular organ that maintains the circulation of the blood.	Hearts
D006352	Heart Ventricles	The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.	Cardiac Ventricle,Cardiac Ventricles,Heart Ventricle,Left Ventricle,Right Ventricle,Left Ventricles,Right Ventricles,Ventricle, Cardiac,Ventricle, Heart,Ventricle, Left,Ventricle, Right,Ventricles, Cardiac,Ventricles, Heart,Ventricles, Left,Ventricles, Right
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia