Both benign and malignant varieties of the mesenchymoma have been described. Previously reported cases of mesenchymoma in the head and neck are rare. Two cases of mesenchymoma occuring intraorally are reported here. In each case local excision has affected apparent cure, for periods of 12 yr and 8 mo, respectively. Local excision is advocated as the primary treatment for such lesions occurring in the oral cavity. Although recurrences in areas other than the oral cavity tend to undergo malignant changes, this phenomenon has bot been demonstrated in lesions occurring in oral tissues.