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Most of the topical otic preparations have been shown to cause ototoxicity. In this study ciprofloxacin hydrochloride, a relatively new topical agent, and gentamicin sulfate were studied in two groups of 20 patients with chronic otitis media. Patients were randomly selected to receive either ciprofloxacin (200 microg/ml) or gentamicin sulfate (5 mg/ml) locally, five drops three times a day for 10 days. Clinical response was seen in 20 of 20 patients in the ciprofloxacin group compared with 6 of 20 patients in the gentamicin group. Audiometric evaluation revealed no significant ototoxic effect in either group. In fact, hearing thresholds were slightly better than pretreatment levels in both groups.
A Ozagar, and
A Koç, and
A Ciprut, and
A Tutkun, and
F Akdaş, and
M A Sehitoğlu
January 2015,
Indian journal of pharmaceutical sciences,
A Ozagar, and
A Koç, and
A Ciprut, and
A Tutkun, and
F Akdaş, and
M A Sehitoğlu
August 1995,
Archives of otolaryngology--head & neck surgery,
A Ozagar, and
A Koç, and
A Ciprut, and
A Tutkun, and
F Akdaş, and
M A Sehitoğlu
April 1989,
The Annals of otology, rhinology, and laryngology,
A Ozagar, and
A Koç, and
A Ciprut, and
A Tutkun, and
F Akdaş, and
M A Sehitoğlu
January 1973,
Acta oto-rhino-laryngologica Belgica,
A Ozagar, and
A Koç, and
A Ciprut, and
A Tutkun, and
F Akdaş, and
M A Sehitoğlu
July 1993,
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery,
A Ozagar, and
A Koç, and
A Ciprut, and
A Tutkun, and
F Akdaş, and
M A Sehitoğlu
August 2002,
Ear, nose, & throat journal,
A Ozagar, and
A Koç, and
A Ciprut, and
A Tutkun, and
F Akdaş, and
M A Sehitoğlu
January 2009,
Otolaryngologia polska = The Polish otolaryngology,
A Ozagar, and
A Koç, and
A Ciprut, and
A Tutkun, and
F Akdaş, and
M A Sehitoğlu
October 1970,
Medicina interna,
A Ozagar, and
A Koç, and
A Ciprut, and
A Tutkun, and
F Akdaş, and
M A Sehitoğlu
May 1970,
Jibi inkoka Otolaryngology,
A Ozagar, and
A Koç, and
A Ciprut, and
A Tutkun, and
F Akdaş, and
M A Sehitoğlu
September 1991,
Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences,
