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Venous thrombosis is a relatively usual but serious complication of permanent transvenous pacing. However, the pathogenesis has not been defined. To clarify underlying abnormalities in the coagulation-fibrinolysis system in patients with permanent transvenous pacemakers, we measured serum levels of fibrinopeptide A (FPA), thrombin-antithrombin III complexes (TATs), plasmin-alpha 2 plasmin inhibitor complexes (PICs), D-dimer (D-D), beta-thromboglobulin (beta-TG), and platelet factor 4 (PF4) in 53 patients with permanent transvenous pacemakers and 10 control subjects. The patients were divided into two groups, as follows, according to the presence of mural thrombus documented along the pacing lead(s) by digital subtraction angiography and transesophageal echocardiography: Group Th (-), patients without venous route thrombus; and Group Th (+), patients with venous route thrombus. FPA and TAT levels increased significantly even in Group Th (-), and further increased in Group Th (+) compared with control subjects (FPA: 7.5 +/- 4.9, 15.3 +/- 8.8 vs 3.0 +/- 1.4 ng/mL, respectively, P < 0.05; TAT: 2.9 +/- 1.3, 4.8 +/- 2.3 vs 1.7 +/- 0.6 ng/mL, respectively, P < 0.05). There were no differences in levels of D-D, PIG, beta-TG, and PF4 among control subjects, Group Th (-), and Group Th (+). These findings suggest that the hypercoagulable state appears in patients with permanent transvenous pacemakers, even without apparent venous thrombosis. The patients with permanent transvenous pacemakers are thought to be in the prethrombotic state even if they have no venous route thrombosis.
T Ito, and
J Tanouchi, and
J Kato, and
M Nishino, and
K Iwai, and
H Tanahashi, and
M Hori, and
Y Yamada, and
T Kamada
March 1970,
New York state journal of medicine,
T Ito, and
J Tanouchi, and
J Kato, and
M Nishino, and
K Iwai, and
H Tanahashi, and
M Hori, and
Y Yamada, and
T Kamada
January 1975,
The Journal of thoracic and cardiovascular surgery,
T Ito, and
J Tanouchi, and
J Kato, and
M Nishino, and
K Iwai, and
H Tanahashi, and
M Hori, and
Y Yamada, and
T Kamada
November 1974,
British heart journal,
T Ito, and
J Tanouchi, and
J Kato, and
M Nishino, and
K Iwai, and
H Tanahashi, and
M Hori, and
Y Yamada, and
T Kamada
February 1992,
Kokyu to junkan. Respiration & circulation,
T Ito, and
J Tanouchi, and
J Kato, and
M Nishino, and
K Iwai, and
H Tanahashi, and
M Hori, and
Y Yamada, and
T Kamada
July 1980,
Pacing and clinical electrophysiology : PACE,
T Ito, and
J Tanouchi, and
J Kato, and
M Nishino, and
K Iwai, and
H Tanahashi, and
M Hori, and
Y Yamada, and
T Kamada
July 1977,
The Journal of thoracic and cardiovascular surgery,
T Ito, and
J Tanouchi, and
J Kato, and
M Nishino, and
K Iwai, and
H Tanahashi, and
M Hori, and
Y Yamada, and
T Kamada
January 1997,
Srpski arhiv za celokupno lekarstvo,
T Ito, and
J Tanouchi, and
J Kato, and
M Nishino, and
K Iwai, and
H Tanahashi, and
M Hori, and
Y Yamada, and
T Kamada
November 1967,
American journal of surgery,
T Ito, and
J Tanouchi, and
J Kato, and
M Nishino, and
K Iwai, and
H Tanahashi, and
M Hori, and
Y Yamada, and
T Kamada
August 1968,
The Journal of the Kentucky Medical Association,
T Ito, and
J Tanouchi, and
J Kato, and
M Nishino, and
K Iwai, and
H Tanahashi, and
M Hori, and
Y Yamada, and
T Kamada
December 2016,
Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology,
