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Poxvirus infection of a domestic cat is reported. The clinical signs consisted of skin lesions only, which healed within two and a half months. Histopathology revealed cytoplasmatic inclusion bodies typical of pox virus infection. Virus particles morphologically related to the genus orthopoxvirus were detectable in the embedded skin tissue and in skin scraping by electron microscopy. No specific lesions were observed in the chick embryo chorioallantoic membrane inoculated with an extraction from skin scabs of the cat.
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