Biomaterial Database

[Toxicity of the PVC-plasticizer di(2-ethylhexyl)phthalate (author's transl)]. 1976

E M Brevik

The plastizicer di(2-ethylhexyl)phthalate (DEHP) is produced in hundreds of thousands tons and has got a widespread use in a multitude of PVC-plast products. In the present review the toxicology and possible harmful environmental effects of DEHP is discussed. The four following topics have also been considered: 1. The solubility of DEHP in water and the complex between DEHP and fulvic acid. 2. Residues and metabolites of DEHP in fish and invertebrates. 3. The metabolites of DEHP in rat, where four major metabolites have been found (fig. 1). 4. The problem concerning residues of DEHP in blood stored in PVC plastic bags for transfusion and the relationship of DEHP to microaggregation of platelets in stored blood. Although the oral LD50 in the rat, mouse and rabbit is about 30 g/kg, its toxicology reveals problematic features such as high toxicity to some invertebrates, specific effects on the nervous system of fish and teratogenic effects in rats.

UI	MeSH Term	Description	Entries
D007928	Lethal Dose 50	The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.	LD50,Dose 50, Lethal
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008322	Mammals	Warm-blooded vertebrate animals belonging to the class Mammalia, including all that possess hair and suckle their young.	Mammalia,Mammal
D010795	Phthalic Acids	A group of compounds that has the general structure of a dicarboxylic acid-substituted benzene ring. The ortho-isomer is used in dye manufacture. (Dorland, 28th ed)	Acids, Phthalic
D002621	Chemistry	A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
D002642	Chick Embryo	The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.	Embryo, Chick,Chick Embryos,Embryos, Chick
D004051	Diethylhexyl Phthalate	An ester of phthalic acid. It appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.	Dioctyl Phthalate,Bis(2-ethylhexyl)phthalate,DEHP,Di(2-ethylhexyl)phthalate,Di-2-Ethylhexylphthalate,Di 2 Ethylhexylphthalate,Phthalate, Diethylhexyl,Phthalate, Dioctyl
D005399	Fishes	A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013045	Species Specificity	The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.	Species Specificities,Specificities, Species,Specificity, Species