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Three adolescents on regular haemodialysis were treated for more than one year with 1alphaOHD3 in doses of 0.25 - 10 mug/day orally. All the patients had hypocalcaemia, a high serum level of alkaline phosphatase and signs of uraemic osteodystrophy on X-ray. Clinical signs of bone disorder were present in two cases. During the treatment serum calcium and alkaline phosphatase normalised, and there was a marked improvement in the X-ray changes. Clinical improvement also took palce but not to the same extent as indicated by the laboratory data. It seems therefore important that treatment should start before severe bone lesions are present. Careful control of the treatment is necessary to avoid hypercalcaemia.
S P Nielsen, and
E Binderup, and
W O Godtfredsen, and
H Jensen, and
J Ladefoged
May 1977,
Calcified tissue research,
S P Nielsen, and
E Binderup, and
W O Godtfredsen, and
H Jensen, and
J Ladefoged
January 1982,
Revista clinica espanola,
S P Nielsen, and
E Binderup, and
W O Godtfredsen, and
H Jensen, and
J Ladefoged
December 1974,
Journal d'urologie et de nephrologie,
S P Nielsen, and
E Binderup, and
W O Godtfredsen, and
H Jensen, and
J Ladefoged
October 1977,
British medical journal,
S P Nielsen, and
E Binderup, and
W O Godtfredsen, and
H Jensen, and
J Ladefoged
September 1977,
British medical journal,
S P Nielsen, and
E Binderup, and
W O Godtfredsen, and
H Jensen, and
J Ladefoged
June 1977,
Archives of disease in childhood,
S P Nielsen, and
E Binderup, and
W O Godtfredsen, and
H Jensen, and
J Ladefoged
January 1981,
Revue du rhumatisme et des maladies osteo-articulaires,
S P Nielsen, and
E Binderup, and
W O Godtfredsen, and
H Jensen, and
J Ladefoged
February 1987,
Transplantation proceedings,
S P Nielsen, and
E Binderup, and
W O Godtfredsen, and
H Jensen, and
J Ladefoged
January 1988,
Experimental pathology,
S P Nielsen, and
E Binderup, and
W O Godtfredsen, and
H Jensen, and
J Ladefoged
May 1982,
Acta pharmacologica et toxicologica,
