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Four microgrammes of 1-alpha-hydroxycholecalciferol (1-alpha-OH D3) or 200 mug of 25-hydroxycholecalciferol (25-OH D3) were given orally every other day respectively to 10 uraemic patients (8 on chronic haemodialysis) for 1-12 weeks and to 3 patients on chronic haemodialysis for 4-8 weeks. A transilial bone biopsy and serial evaluation of serum immunoreactive PTH (iPTH) calcium phosphate and alkaline phosphatase were performed before and at the end of therapy. Both 1-alpha-OH D3 and 25-OH D3 (the latter at a 50 times higher dose) were able to depress hyperparathyroidism in two-thirds of the cases and to consistently improve the mineralisation defect. In no case did iPTH or the bone histomorphometric parameters return to normal, so that long term evaluation of these two drugs is warranted.
A E Fournier, and
P J Bordier, and
J Gueris, and
J Chanard, and
P Marie, and
C Ferriere, and
M Osario, and
J Bedrossian, and
H F de Luca
July 1976,
Harefuah,
A E Fournier, and
P J Bordier, and
J Gueris, and
J Chanard, and
P Marie, and
C Ferriere, and
M Osario, and
J Bedrossian, and
H F de Luca
January 1975,
British medical journal,
A E Fournier, and
P J Bordier, and
J Gueris, and
J Chanard, and
P Marie, and
C Ferriere, and
M Osario, and
J Bedrossian, and
H F de Luca
October 1977,
British medical journal,
A E Fournier, and
P J Bordier, and
J Gueris, and
J Chanard, and
P Marie, and
C Ferriere, and
M Osario, and
J Bedrossian, and
H F de Luca
September 1977,
British medical journal,
A E Fournier, and
P J Bordier, and
J Gueris, and
J Chanard, and
P Marie, and
C Ferriere, and
M Osario, and
J Bedrossian, and
H F de Luca
December 1986,
Zentralblatt fur Veterinarmedizin. Reihe A,
A E Fournier, and
P J Bordier, and
J Gueris, and
J Chanard, and
P Marie, and
C Ferriere, and
M Osario, and
J Bedrossian, and
H F de Luca
October 1979,
Pediatric research,
A E Fournier, and
P J Bordier, and
J Gueris, and
J Chanard, and
P Marie, and
C Ferriere, and
M Osario, and
J Bedrossian, and
H F de Luca
December 1974,
Journal d'urologie et de nephrologie,
A E Fournier, and
P J Bordier, and
J Gueris, and
J Chanard, and
P Marie, and
C Ferriere, and
M Osario, and
J Bedrossian, and
H F de Luca
April 1977,
Lancet (London, England),
A E Fournier, and
P J Bordier, and
J Gueris, and
J Chanard, and
P Marie, and
C Ferriere, and
M Osario, and
J Bedrossian, and
H F de Luca
May 1992,
Biochemical and biophysical research communications,
A E Fournier, and
P J Bordier, and
J Gueris, and
J Chanard, and
P Marie, and
C Ferriere, and
M Osario, and
J Bedrossian, and
H F de Luca
July 1981,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
