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Peripheral blood progenitor cell transplantation as an alternative to autologous marrow transplantation in the treatment of acute myeloid leukemia. 1997
B Löwenberg, and
W L van Putten, and
A Ferrant, and
G Ossenkoppele, and
E Vellenga, and
L F Verdonck, and
A Gratwohl, and
M A Boogaerts
Dr. Daniel den Hoed Cancer Center, Erasmus University, Rotterdam, The Netherlands.
Herein we report on the feasibility of mobilizing peripheral blood progenitor cells (PBPC) in a prospective study of the HOVON-SAKK Groups in 96 cases with newly diagnosed acute myeloid leukemia (AML). Among 96 patients, 76 patients (79%) entered complete remission. Mobilization was undertaken with variable dosages of G-CSF in 63 patients, and 54 patients (87%) were leukapheresed. The comparative yields of pheresis following the G-CSF schedules and hematopoietic recovery data are presented and discussed. PBPC transplantation results in faster hematopoietic regeneration compared to autologous marrow grafting in the prior AML HOVON study.
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