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L-DOPA neurotoxicity is mediated by glutamate release in cultured rat striatal neurons. 1997
T Maeda, and
N Cheng, and
T Kume, and
S Kaneko, and
H Kouchiyama, and
A Akaike, and
M Ueda, and
M Satoh, and
Y Goshima, and
Y Misu
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
The exposure of cultured rat striatal neurons to L-DOPA caused marked cell death. The L-DOPA cytotoxicity was inhibited by the addition of Mg2+ to and by the removal of Ca2+ from the culture medium, and also by the application of tetrodotoxin. Moreover, prolonged application of L-DOPA increased the glutamate content in the culture medium. These results indicate that L-DOPA produces neurotoxicity by facilitating glutamate release.
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