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Thirty-nine carriers of hepatitis B surface antigen (HBs Ag) were studied with respect to e antigen and Dane particle-associated DNA polymerase activity and their relation to chronic hepatitis. Most of these individuals were followed for four or five years. A strong correlation between e antigen and DNA polymerase activity was found. Of the 22 e antigen-positive patients, 21 showed polymerase activity; none of the 13 e antigen-negative patients (one of whom had antibody to e antigen) had such activity. Three of four patients who became e antigen-negative after being e antigen-positive showed loss of polymerase activity. An independent clinical evaluation showed a strong correlation between chronic hepatitis and positive reactions in the tests for e antigen and DNA polymerase. The results emphasize the possibility of differentiating between groups of chronic carriers of HBs Ag by testing for e antigen and Dane particle-associated DNA polymerase activity. The differentiation may have important clinical implications.
E Nordenfelt, and
M Andrén-Sandberg
January 1979,
Infection,
E Nordenfelt, and
M Andrén-Sandberg
May 1977,
Proceedings of the National Academy of Sciences of the United States of America,
E Nordenfelt, and
M Andrén-Sandberg
January 1979,
Infection,
E Nordenfelt, and
M Andrén-Sandberg
January 1975,
Intervirology,
E Nordenfelt, and
M Andrén-Sandberg
January 1979,
Journal of medical virology,
E Nordenfelt, and
M Andrén-Sandberg
January 1982,
Hepatology (Baltimore, Md.),
E Nordenfelt, and
M Andrén-Sandberg
January 1978,
Journal of medical virology,
E Nordenfelt, and
M Andrén-Sandberg
February 1977,
Journal of virology,
E Nordenfelt, and
M Andrén-Sandberg
July 1977,
The Journal of general virology,
E Nordenfelt, and
M Andrén-Sandberg
February 1979,
Acta pathologica et microbiologica Scandinavica. Section B, Microbiology,
