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The relationship between the number of fibers injected intraperitoneally and the occurrence of peritoneal mesotheliomas in rats was investigated using data from a series of carcinogenicity studies with several fibrous dusts. Based on observed tumor incidences ranging between 10 and 90%, the hypothesis of a common slope of dose-response relationships (parallel probit lines in probit analysis) cannot be rejected. In general, parallelism of probit lines is considered an indication of a common mode of action. Analysis of the shape of the dose-response relationship, with one apparent exception, shows virtually linear or superlinear behavior, i.e., from these data, there is no indication of a decrease in carcinogenic potency of an elementary carcinogenic unit at lower doses.
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K Kamino, and
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B Bellmann
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G H Althoff, and
B Bellmann
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B Bellmann
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M Roller, and
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B Bellmann
January 1989,
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M Roller, and
F Pott, and
K Kamino, and
G H Althoff, and
B Bellmann
December 1983,
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