BIOMAT Database Logo BIOMAT Database Logo

Circulating soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in patients with gastric cancer. 1997

G Velikova, and R E Banks, and A Gearing, and I Hemingway, and M A Forbes, and S R Preston, and M Jones, and J Wyatt, and K Miller, and U Ward, and J Al-Maskatti, and S M Singh, and N S Ambrose, and J N Primrose, and P J Selby
ICRF Cancer Medicine Research Unit, St James's University Hospital, Leeds, UK.

The concentrations of the soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were investigated in 45 patients with gastric cancer before treatment and their correlation with clinical, histological and routine laboratory parameters was examined. Data were collected on tumour stage at presentation, presence and sites of metastatic disease, tumour pathology, survival and results of routine laboratory tests. Serum concentrations of ICAM-1 and VCAM-1 were significantly elevated in the patients with gastric cancer in comparison with the group of healthy subjects (P < 0.00001 and P < 0.0001 respectively). Increased serum concentrations of VCAM-1 were associated with locally advanced and metastatic disease whereas ICAM-1 was significantly elevated both in local and in advanced/metastatic disease. Soluble E-cadherin and E-selectin concentrations did not show any significant elevation in gastric cancer patients. Concentrations of soluble adhesion molecules showed significant correlation with each other (except E-selectin and VCAM-1) and with alkaline phosphatase. Soluble ICAM-1 and VCAM-1 were significantly associated with an elevated total white cell count. Patients with elevated VCAM-1 had significantly poorer survival in comparison with patients with normal serum levels (P = 0.0361).

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000369 Aged, 80 and over Persons 80 years of age and older. Oldest Old
D012995 Solubility The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Solubilities
D013274 Stomach Neoplasms Tumors or cancer of the STOMACH. Cancer of Stomach,Gastric Cancer,Gastric Neoplasms,Stomach Cancer,Cancer of the Stomach,Gastric Cancer, Familial Diffuse,Neoplasms, Gastric,Neoplasms, Stomach,Cancer, Gastric,Cancer, Stomach,Cancers, Gastric,Cancers, Stomach,Gastric Cancers,Gastric Neoplasm,Neoplasm, Gastric,Neoplasm, Stomach,Stomach Cancers,Stomach Neoplasm
D015820 Cadherins Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body. Cadherin,E-Cadherins,Epithelial-Cadherin,Liver Cell Adhesion Molecules,N-Cadherins,Neural Cadherin,P-Cadherins,Uvomorulin,Cadherin-1,Cadherin-2,Cadherin-3,E-Cadherin,Epithelial-Cadherins,Liver Cell Adhesion Molecule,N-Cadherin,Neural Cadherins,P-Cadherin,Placental Cadherins,Cadherin 1,Cadherin 2,Cadherin 3,Cadherin, Neural,Cadherins, Neural,Cadherins, Placental,E Cadherin,E Cadherins,Epithelial Cadherin,Epithelial Cadherins,N Cadherin,N Cadherins,P Cadherin,P Cadherins

Related Publications

G Velikova, and R E Banks, and A Gearing, and I Hemingway, and M A Forbes, and S R Preston, and M Jones, and J Wyatt, and K Miller, and U Ward, and J Al-Maskatti, and S M Singh, and N S Ambrose, and J N Primrose, and P J Selby
Circulating intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin in urological malignancies.
March 2001, Indian journal of cancer,
G Velikova, and R E Banks, and A Gearing, and I Hemingway, and M A Forbes, and S R Preston, and M Jones, and J Wyatt, and K Miller, and U Ward, and J Al-Maskatti, and S M Singh, and N S Ambrose, and J N Primrose, and P J Selby
Circulating intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1) in human malignancies.
July 1993, British journal of cancer,
G Velikova, and R E Banks, and A Gearing, and I Hemingway, and M A Forbes, and S R Preston, and M Jones, and J Wyatt, and K Miller, and U Ward, and J Al-Maskatti, and S M Singh, and N S Ambrose, and J N Primrose, and P J Selby
Circulating intercellular adhesion molecule 1 (ICAM-1), E-selectin and vascular cell adhesion molecule 1 (VCAM-1) in head and neck cancer.
January 1999, British journal of cancer,
G Velikova, and R E Banks, and A Gearing, and I Hemingway, and M A Forbes, and S R Preston, and M Jones, and J Wyatt, and K Miller, and U Ward, and J Al-Maskatti, and S M Singh, and N S Ambrose, and J N Primrose, and P J Selby
Soluble adhesion molecules E-cadherin, intercellular adhesion molecule-1, and E-selectin as lung cancer biomarkers.
November 2010, Chest,
G Velikova, and R E Banks, and A Gearing, and I Hemingway, and M A Forbes, and S R Preston, and M Jones, and J Wyatt, and K Miller, and U Ward, and J Al-Maskatti, and S M Singh, and N S Ambrose, and J N Primrose, and P J Selby
Circulating vascular cell adhesion molecules VCAM-1, ICAM-1, and E-selectin in dependence on aging.
January 2003, Gerontology,
G Velikova, and R E Banks, and A Gearing, and I Hemingway, and M A Forbes, and S R Preston, and M Jones, and J Wyatt, and K Miller, and U Ward, and J Al-Maskatti, and S M Singh, and N S Ambrose, and J N Primrose, and P J Selby
Adhesion molecules (E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1)) in sera from patients with Staphylococcus aureus bacteraemia with or without endocarditis.
December 1999, Clinical and experimental immunology,
G Velikova, and R E Banks, and A Gearing, and I Hemingway, and M A Forbes, and S R Preston, and M Jones, and J Wyatt, and K Miller, and U Ward, and J Al-Maskatti, and S M Singh, and N S Ambrose, and J N Primrose, and P J Selby
Synchronous elevation of soluble intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) correlates with gastric cancer progression.
February 1998, Yonsei medical journal,
G Velikova, and R E Banks, and A Gearing, and I Hemingway, and M A Forbes, and S R Preston, and M Jones, and J Wyatt, and K Miller, and U Ward, and J Al-Maskatti, and S M Singh, and N S Ambrose, and J N Primrose, and P J Selby
Expression of E-selectin, intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 in non-small-cell lung carcinoma.
April 1996, Virchows Archiv : an international journal of pathology,
G Velikova, and R E Banks, and A Gearing, and I Hemingway, and M A Forbes, and S R Preston, and M Jones, and J Wyatt, and K Miller, and U Ward, and J Al-Maskatti, and S M Singh, and N S Ambrose, and J N Primrose, and P J Selby
Soluble forms of vascular adhesion molecules, E-selectin, ICAM-1, and VCAM-1: pathological significance.
December 1992, Annals of the New York Academy of Sciences,
G Velikova, and R E Banks, and A Gearing, and I Hemingway, and M A Forbes, and S R Preston, and M Jones, and J Wyatt, and K Miller, and U Ward, and J Al-Maskatti, and S M Singh, and N S Ambrose, and J N Primrose, and P J Selby
Soluble adhesion molecules (E-selectin, ICAM-1 and VCAM-1) in breast carcinoma.
November 2002, European journal of cancer (Oxford, England : 1990),
Copied contents to your clipboard!