-transparent.png){kind=logo}
Synthesis of a series of thienylethanolamines having varying substituents on the thiophene ring and on the nitrogen atom is described using the general procedure reported earlier. In the determination of their pharmacological profile, some of the derivatives showed marked antihypertensive activity in the spontaneously hypertensive rat model. Tests are also reported which demonstrated that some of these derivatives antagonized alpha- and/or beta-adrenoreceptor activities. The ability of this class of compounds to inhibit catecholamine-induced release of free fatty acids by adipose tissue was demonstrated. Structure-activity relationships in different tests were also determined.
J F Bagli, and
W D Mackay, and
E Ferdinandi
January 1990,
Yao xue xue bao = Acta pharmaceutica Sinica,
J F Bagli, and
W D Mackay, and
E Ferdinandi
November 1976,
Journal of medicinal chemistry,
J F Bagli, and
W D Mackay, and
E Ferdinandi
October 1983,
Journal of medicinal chemistry,
J F Bagli, and
W D Mackay, and
E Ferdinandi
February 1989,
Farmaco (Societa chimica italiana : 1989),
J F Bagli, and
W D Mackay, and
E Ferdinandi
February 1982,
Chemical & pharmaceutical bulletin,
J F Bagli, and
W D Mackay, and
E Ferdinandi
October 1988,
Archiv der Pharmazie,
J F Bagli, and
W D Mackay, and
E Ferdinandi
August 1978,
Journal of medicinal chemistry,
J F Bagli, and
W D Mackay, and
E Ferdinandi
February 1991,
Farmaco (Societa chimica italiana : 1989),
J F Bagli, and
W D Mackay, and
E Ferdinandi
January 1983,
Acta pharmaceutica Suecica,
J F Bagli, and
W D Mackay, and
E Ferdinandi
January 1987,
Acta pharmaceutica Suecica,
