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In five mechanically ventilated rabbits, we studied the property of inhaled nitric oxide in helping to treat hypoxaemia which was induced by intravenous endotoxin (Escherichia coli-derived lipopolysaccharide, serotype 0111: B4). We used measurements of arterial partial pressure of oxygen to check a therapeutic nitric oxide benefit. Pulmonary artery pressure was continuously monitored. Furthermore, we determined the single-breath diffusing capacity for nitric oxide. Measurements of plasma nitrite/nitrate concentration served as an indicator of endogenous nitric oxide output. The first infusion of endotoxin led to a transient pulmonary vasoconstriction, whereas arterial partial pressure of oxygen was permanently reduced by 30 +/- 10 mmHg (mean +/- SD), attaining minimal values of 48 +/- 3.4 mmHg due to additional endotoxin. Single-breath diffusing capacity for nitric oxide declined by 20 +/- 5.5% of baseline values until the experiments were concluded. Endotoxin induced an increase in plasma nitrite/nitrate concentration in the five rabbits as well as in the control animals (four rabbits) without exogenous nitric oxide supply. During the 25 inhalations of nitric oxide (3-50 ppm), arterial oxygenation did not change significantly. Thus endotoxin permanently impaired pulmonary gas exchange without inducing pulmonary hypertension. Inhaled nitric oxide did not improve arterial oxygenation during endotoxaemia.
H Heller, and
G Hoffmann, and
W Schobersberger, and
K D Schuster
March 1997,
Acta anaesthesiologica Scandinavica,
H Heller, and
G Hoffmann, and
W Schobersberger, and
K D Schuster
August 1996,
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases,
H Heller, and
G Hoffmann, and
W Schobersberger, and
K D Schuster
February 2000,
Intensive care medicine,
H Heller, and
G Hoffmann, and
W Schobersberger, and
K D Schuster
May 1999,
Zhonghua wai ke za zhi [Chinese journal of surgery],
H Heller, and
G Hoffmann, and
W Schobersberger, and
K D Schuster
January 1997,
International journal of tissue reactions,
H Heller, and
G Hoffmann, and
W Schobersberger, and
K D Schuster
December 2006,
Anaesthesia,
H Heller, and
G Hoffmann, and
W Schobersberger, and
K D Schuster
February 1999,
Pediatric research,
H Heller, and
G Hoffmann, and
W Schobersberger, and
K D Schuster
October 1995,
Journal of applied physiology (Bethesda, Md. : 1985),
H Heller, and
G Hoffmann, and
W Schobersberger, and
K D Schuster
November 2001,
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
H Heller, and
G Hoffmann, and
W Schobersberger, and
K D Schuster
July 1994,
Lancet (London, England),
