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The benzodiazepine agonist, diazepam, inhibits cAMP production in the rat brain. Since cAMP influences c-fos activity, we examined the effects of diazepam on expression of this immediate early gene, as indicated by Western blot analysis. Intraperitoneal administration of diazepam increased Fos protein levels in the striatum, but not in the hippocampus. In contrast, pretreatment with diazepam blocked the potent inducing effect of amphetamine, in both brain regions. Similar induction and blockade effects were also observed for a 90 kDa Fos related antigen (Fra), in the striatum and hippocampus. The possible mechanisms underlying the modulatory effects of diazepam on c-fos expression in the brain are discussed.
L P Niles, and
L J Smith, and
C C Tenn
April 1990,
Journal of neurochemistry,
L P Niles, and
L J Smith, and
C C Tenn
February 1993,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
L P Niles, and
L J Smith, and
C C Tenn
June 2005,
Brain research. Developmental brain research,
L P Niles, and
L J Smith, and
C C Tenn
January 2001,
Brain research bulletin,
L P Niles, and
L J Smith, and
C C Tenn
April 2002,
Brain research,
L P Niles, and
L J Smith, and
C C Tenn
January 2007,
Journal of molecular neuroscience : MN,
L P Niles, and
L J Smith, and
C C Tenn
October 1996,
Anesthesiology,
L P Niles, and
L J Smith, and
C C Tenn
January 2002,
Cell biology international,
L P Niles, and
L J Smith, and
C C Tenn
October 2004,
Psychiatry and clinical neurosciences,
L P Niles, and
L J Smith, and
C C Tenn
January 2001,
Neuroscience,
