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Oxygen reactive species play a significant role in reperfusion tissue damages. In this study we aimed to investigate the mechanisms of injury regarding changes of neutrophil function. In our experiments the left descending coronary artery (LAD) was ligated in Beagle dogs for 1 hour followed by one hour reperfusion. Animals were divided into two groups: Group I. dogs (n = 10) served as control: Group II. the animals (n = 10) were treated by cardioprotective drug Bisaramil. Peripheral blood samples were taken for neutrophil isolation before operation and subsequent reperfusion (5 min, 1 hour). The stimulated superoxide radical generating capacity of polymorphonuclear leukocytes (PMN) was measured. The lipid peroxidation (MDA), amount of reduced glutathione (GSH) and activity of superoxide dismutase (SOD) were measured in non-ischemic and ischemic parts of left ventricle. There was no significant changes either in control or in treated animals in respect to changes of neutrophil radical production after one hour LAD ligature, however there was a significant discrepancy (p < 0.001) between control and treated animals following a 1 hour reperfusion. The values of MDA in the ischemic-area increased characteristically in the Group I. parallel with decrease of scavenger GSH and SOD. In contrast in Group II., where depleted PMN radical production was observed endogenous scavengers were preserved on a higher level. In summary we can conclude that diminished superoxide radical production of circulating neutrophils during reperfusion has beneficial effects on tissue injury caused especially by free radicals.
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G Varga, and
M Paróczai, and
E Kárpáti
March 2004,
Italian heart journal : official journal of the Italian Federation of Cardiology,
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October 2002,
Heart failure reviews,
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January 2015,
Anesteziologiia i reanimatologiia,
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January 2007,
Experimental and clinical cardiology,
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September 2022,
Circulation research,
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October 2007,
Sheng li xue bao : [Acta physiologica Sinica],
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February 2005,
Cardiovascular research,
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March 2008,
Chinese journal of integrative medicine,
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January 2008,
Free radical biology & medicine,
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M Paróczai, and
E Kárpáti
June 2017,
Molecular and cellular biochemistry,
