-transparent.png){kind=logo}
The prevalence and mortality rate of pulmonary tuberculosis in adults are high in Taiwan. Because the emergence of drug-resistant tuberculosis is one of the major causes of this sustained high tuberculosis mortality, surveillance of initial drug resistance is important. We tested Mycobacterium tuberculosis isolates from 1,935 newly diagnosed tuberculosis patients from January 1990 through December 1995 at the Taiwan Provincial Chronic Disease Control Bureau. The overall initial drug resistance rate was 12.3%; 8.7% of isolates were resistant to only one drug, 2.6% to two drugs, 0.7% to three drugs, and 0.3% to four drugs. The resistance rates to individual drugs were: streptomycin, 5.7%; isoniazid, 9.2%; ethambutol, 0.7%; and rifampin, 1.5%. The frequency of multidrug-resistant M. tuberculosis (resistant to at least isoniazid and rifampin) was 1.2%. In view of the high initial isoniazid resistance rate and low initial ethambutol resistance rate, ethambutol should be added to the regimen for the initial treatment of tuberculosis in Taiwan. The emergence of multidrug-resistant M. tuberculosis is ominous and should be considered when treating patients in Taiwan.
M C Yu, and
J Suo, and
C Y Chiang, and
K J Bai, and
T P Lin, and
K T Luh
October 2004,
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi,
M C Yu, and
J Suo, and
C Y Chiang, and
K J Bai, and
T P Lin, and
K T Luh
May 2006,
Emerging infectious diseases,
M C Yu, and
J Suo, and
C Y Chiang, and
K J Bai, and
T P Lin, and
K T Luh
September 1977,
Zhonghua Minguo wei sheng wu xue za zhi = Chinese journal of microbiology,
M C Yu, and
J Suo, and
C Y Chiang, and
K J Bai, and
T P Lin, and
K T Luh
March 1982,
Problemy tuberkuleza,
M C Yu, and
J Suo, and
C Y Chiang, and
K J Bai, and
T P Lin, and
K T Luh
March 1996,
The Journal of communicable diseases,
M C Yu, and
J Suo, and
C Y Chiang, and
K J Bai, and
T P Lin, and
K T Luh
September 1995,
The European respiratory journal. Supplement,
M C Yu, and
J Suo, and
C Y Chiang, and
K J Bai, and
T P Lin, and
K T Luh
July 2006,
Current issues in molecular biology,
M C Yu, and
J Suo, and
C Y Chiang, and
K J Bai, and
T P Lin, and
K T Luh
September 2004,
Journal of the Formosan Medical Association = Taiwan yi zhi,
M C Yu, and
J Suo, and
C Y Chiang, and
K J Bai, and
T P Lin, and
K T Luh
March 2008,
Journal of the Formosan Medical Association = Taiwan yi zhi,
M C Yu, and
J Suo, and
C Y Chiang, and
K J Bai, and
T P Lin, and
K T Luh
March 1992,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
