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This study demonstrates marked differences in the incidences of sarcomas in Fischer rats within 2 years after a single im injection of 4 insoluble nickel-containing powders: amorphous nickel monosulfide (NiS), nickel subsulfide (alphaNi3S2), partially converted nickel-iron sulfide matte, and metallic nickel. The powders (less than 2 um median particle diameters) were administered in penicillin suspension, and each powder was tested at 2 dosages. Whereas alphaNi3S2 was highly carcinogenic, amorphous NiS did not induce any tumors. The carcinogenic potency of partially converted nickel-iron sulfide matte was less than alphaNi3S2 but greater than Ni powder. No sarcomas occurred at the injection site in two groups of control rats that received im injections of penicillin or Fe powder. The observed differences in carcinogenic potencies of alphaNi3S2 and amorphous NiS may provide an experimental approach to elucidate the molecular mechanisms of nickel carcinogenesis.
F W Sunderman, and
R M Maenza
June 1976,
Preventive medicine,
F W Sunderman, and
R M Maenza
October 1982,
Gan,
F W Sunderman, and
R M Maenza
November 1981,
Cancer letters,
F W Sunderman, and
R M Maenza
January 1985,
Princess Takamatsu symposia,
F W Sunderman, and
R M Maenza
January 1976,
IARC monographs on the evaluation of the carcinogenic risk of chemicals to man,
F W Sunderman, and
R M Maenza
January 1983,
Carcinogenesis,
F W Sunderman, and
R M Maenza
January 2004,
Report on carcinogens : carcinogen profiles,
F W Sunderman, and
R M Maenza
January 1997,
Journal of applied toxicology : JAT,
F W Sunderman, and
R M Maenza
January 2011,
Report on carcinogens : carcinogen profiles,
F W Sunderman, and
R M Maenza
January 2002,
Report on carcinogens : carcinogen profiles,
