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[Immunochemical analysis of human monoclonal IGM with antibody cold agglutinin activity during Mycoplasma pneumoniae infection]. 1996
F Ben Aïssa-Fennira, and
A Bouguerra, and
R Hafsia, and
D Dellagi, and
A Ben Ammar-el Gaaied, and
K Dellagi
Laboratoire d'Hématologie et d'Immunopathologie, Faculté de Médecine de Tunis.
Mycoplasma pneumoniae (MP) infection is associated with the emergence of anti-I cold agglutinins of IgM isotype, rarely complicated by hemolytic anemia. The mechanism by which the autoimmune disease occurs is still considerably controversed. We describe here a case of MP infection complicated by severe autoimmune hemolytic anemia with monoclonal anti-I IgM. IgM anti-I antibodies were purified by adsorption-elution on OI+ red cells. The red blood cell antibodies were found to be tightly associated with IgG and anti-MP specificity probably as immune complexes. The significance of these results is discussed.
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