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OBJECTIVE We investigated the cardiac effects of an ionic dimer, ioxaglate and two nonionic dimers, iotrolan, and iodixanol. METHODS During a simulated wedged catheter situation, 22 ml of each contrast medium was injected into the left anterior descending branch of the left coronary artery in seven open-chested, anesthetized dogs. RESULTS Of 13 injections with each contrast medium, ioxaglate induced ventricular fibrillation in 11 after 34 +/- 5 sec, iotrolan in 6 after 42 +/- 4 sec, and iodixanol in 3 after 61 +/- 1 sec. Ioxaglate markedly lengthened monophasic action potential duration in contrast medium-perfused myocardium. Iotrolan, and iodixanol induced biphasic changes, first lengthening and then shortening action potential duration. The electrophysiological changes occurred later when using iodixanol. CONCLUSIONS The risk of ventricular fibrillation during long-lasting contrast media exposure to the myocardium, as in a wedged catheter situation, appears to be much lower with iodixanol compared with ioxaglate and also lower than when using iotrolan.
H K Pedersen, and
E A Jacobsen, and
H Refsum
January 1988,
Acta radiologica (Stockholm, Sweden : 1987),
H K Pedersen, and
E A Jacobsen, and
H Refsum
September 1988,
Investigative radiology,
H K Pedersen, and
E A Jacobsen, and
H Refsum
December 1983,
Israel journal of medical sciences,
H K Pedersen, and
E A Jacobsen, and
H Refsum
April 1989,
Investigative radiology,
H K Pedersen, and
E A Jacobsen, and
H Refsum
March 1977,
Acta radiologica: diagnosis,
H K Pedersen, and
E A Jacobsen, and
H Refsum
January 1979,
Investigative radiology,
H K Pedersen, and
E A Jacobsen, and
H Refsum
July 2007,
The Journal of veterinary medical science,
H K Pedersen, and
E A Jacobsen, and
H Refsum
October 2005,
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin,
H K Pedersen, and
E A Jacobsen, and
H Refsum
January 1995,
Acta radiologica. Supplementum,
H K Pedersen, and
E A Jacobsen, and
H Refsum
October 1953,
Surgical forum,
