-transparent.png){kind=logo}
BACKGROUND Inhaled nitric oxide has been shown to improve oxygenation in select patients with acute respiratory distress syndrome (ARDS). OBJECTIVE The purpose of this study was to evaluate the clinical response to four concentrations of inhaled nitric oxide (NO) in 20 patients with ARDS. METHODS All patients with ARDS were eligible for the study. ARDS was defined as (1) the presence of a predisposing factor; (2) a PaO2/FiO2 ratio < 200; (3) bilateral infiltrates on chest radiograph; and (4) absence of evidence of congestive heart failure and pulmonary artery wedge pressure < 18 mm Hg. Patients received each of four doses (1, 15, 30, and 60 ppm) in random order, each for a 3-hour period. Cardiovascular variables were continuously monitored, and arterial and mixed venous blood gas measurements were obtained at 30 minutes and 3 hours. RESULTS Thirteen of the 20 patients demonstrated a significant increase in their PaO2/FiO2 (> 20% increase) when treated with inhaled NO. The administration of inhaled NO was associated with an increase in oxygenation at doses of 1, 15, and 30 ppm, but not 60 ppm. Increasing NO dose to more than 1 ppm did not significantly improve response. Mean pulmonary artery pressure decreased with increasing NO concentration, but this did not reach statistical significance. Nine of the 13 responding patients and 2 of the 7 nonresponding patients survived. CONCLUSIONS Inhaled NO was successful in increasing PaO2/FiO2 by > 20% in 65% of the surgical patients in this trial. Response to NO could not be predicted by initial PaO2/FiO2 or pulmonary artery pressures. A trial of inhaled NO at a dose of < 10 ppm may be helpful in ARDS patients requiring increasing FiO2 and positive end-expiratory pressure.
J A Johannigman, and
K Davis, and
R S Campbell, and
F Luchette, and
J M Hurst, and
R D Branson
December 1998,
Respiratory care clinics of North America,
J A Johannigman, and
K Davis, and
R S Campbell, and
F Luchette, and
J M Hurst, and
R D Branson
April 2007,
BMJ (Clinical research ed.),
J A Johannigman, and
K Davis, and
R S Campbell, and
F Luchette, and
J M Hurst, and
R D Branson
August 1999,
American journal of respiratory and critical care medicine,
J A Johannigman, and
K Davis, and
R S Campbell, and
F Luchette, and
J M Hurst, and
R D Branson
December 2006,
Revista Brasileira de terapia intensiva,
J A Johannigman, and
K Davis, and
R S Campbell, and
F Luchette, and
J M Hurst, and
R D Branson
November 1998,
The European respiratory journal,
J A Johannigman, and
K Davis, and
R S Campbell, and
F Luchette, and
J M Hurst, and
R D Branson
February 2000,
Critical care medicine,
J A Johannigman, and
K Davis, and
R S Campbell, and
F Luchette, and
J M Hurst, and
R D Branson
March 2017,
Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria,
J A Johannigman, and
K Davis, and
R S Campbell, and
F Luchette, and
J M Hurst, and
R D Branson
December 2002,
Hospital medicine (London, England : 1998),
J A Johannigman, and
K Davis, and
R S Campbell, and
F Luchette, and
J M Hurst, and
R D Branson
November 2000,
Respiratory medicine,
J A Johannigman, and
K Davis, and
R S Campbell, and
F Luchette, and
J M Hurst, and
R D Branson
July 2012,
Indian pediatrics,
