Biomaterial Database

Recovery after intravenous sedation. A comparison of clinical and paper and pencil tests used in assessing late effects of diazepam. 1976

K Korttila

Twelve healthy subjects received intravenously 0-15 mg/kg of diazepam twice, with a two-week interval between doses. They were tested in a cross-over manner before and after the injection either with a clinical test battery plus paper and pencil tests, or with a carefully selected psychomotor test battery having a correlation to real traffic behavior. Neither the clinical tests nor the paper and pencil tests demonstrated impairment of performance 1/2 and 2 1/2 hours after the injection, whereas the psychomotor tests revealed considerable impairment of reactive and co-ordinative skills 2 1/2 hours after the injection. The results stress the importance of the presence of an escort when patients are discharged from hospital after outpatient anaesthesia or sedation.

UI	MeSH Term	Description	Entries
D006993	Hypnotics and Sedatives	Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.	Hypnotic,Sedative,Sedative and Hypnotic,Sedatives,Hypnotic Effect,Hypnotic Effects,Hypnotics,Sedative Effect,Sedative Effects,Sedatives and Hypnotics,Effect, Hypnotic,Effect, Sedative,Effects, Hypnotic,Effects, Sedative,Hypnotic and Sedative
D007275	Injections, Intravenous	Injections made into a vein for therapeutic or experimental purposes.	Intravenous Injections,Injection, Intravenous,Intravenous Injection
D008297	Male		Males
D009048	Motor Skills	Performance of complex motor acts.	Motor Skill,Skill, Motor,Skills, Motor
D011581	Psychological Tests	Standardized tests designed to measure abilities (as in intelligence, aptitude, and achievement tests) or to evaluate personality traits.	Parenting Stress Index,Trier Social Stress Test,Trier Stress Test,Psychologic Tests,Psychological Test,Test, Psychological,Tests, Psychological,Index, Parenting Stress,Psychologic Test,Stress Index, Parenting,Stress Test, Trier,Test, Psychologic,Test, Trier Stress,Trier Stress Tests
D011930	Reaction Time	The time from the onset of a stimulus until a response is observed.	Response Latency,Response Speed,Response Time,Latency, Response,Reaction Times,Response Latencies,Response Times,Speed, Response,Speeds, Response
D003975	Diazepam	A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.	7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one,Apaurin,Diazemuls,Faustan,Relanium,Seduxen,Sibazon,Stesolid,Valium
D005133	Eye Movements	Voluntary or reflex-controlled movements of the eye.	Eye Movement,Movement, Eye,Movements, Eye
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man