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An amino acid type poly(ethylene glycol) (aaPPEG) was prepared and its application to a drug carrier was examined. The peptides, Arg-Gly-Asp (RGD) and Glu-Ile-Leu-Asp-Val (EILDV) which were reported as active fragments of Fibronectin (a cell adhesion protein), were conjugated with aaPEG (molecular weight, 10,000). The hybrid, RGD-aaPEG-EILDV, was prepared by a combination of the solid-phase method and the solution method. Antiadhesive activity of the peptides was not lost by its hybrid formation with the large aaPEG molecule. A mixture of RGD (0.43 mmol) and EILDV (0.43 mmol) did not demonstrate an antiadhesive effect, but the hybrid containing 0.43 mmol of each peptide did exhibit this effect.
M Maeda, and
Y Izuno, and
K Kawasaki, and
Y Kaneda, and
Y Mu, and
Y Tsutsumi, and
K W Lem, and
T Mayumi
July 1998,
Biochemical and biophysical research communications,
M Maeda, and
Y Izuno, and
K Kawasaki, and
Y Kaneda, and
Y Mu, and
Y Tsutsumi, and
K W Lem, and
T Mayumi
December 1995,
Chemical & pharmaceutical bulletin,
M Maeda, and
Y Izuno, and
K Kawasaki, and
Y Kaneda, and
Y Mu, and
Y Tsutsumi, and
K W Lem, and
T Mayumi
June 2001,
Bioorganic & medicinal chemistry letters,
M Maeda, and
Y Izuno, and
K Kawasaki, and
Y Kaneda, and
Y Mu, and
Y Tsutsumi, and
K W Lem, and
T Mayumi
November 1993,
Chemical & pharmaceutical bulletin,
M Maeda, and
Y Izuno, and
K Kawasaki, and
Y Kaneda, and
Y Mu, and
Y Tsutsumi, and
K W Lem, and
T Mayumi
June 1994,
Biological & pharmaceutical bulletin,
M Maeda, and
Y Izuno, and
K Kawasaki, and
Y Kaneda, and
Y Mu, and
Y Tsutsumi, and
K W Lem, and
T Mayumi
January 1974,
Biochemistry,
M Maeda, and
Y Izuno, and
K Kawasaki, and
Y Kaneda, and
Y Mu, and
Y Tsutsumi, and
K W Lem, and
T Mayumi
April 2001,
Chemical & pharmaceutical bulletin,
M Maeda, and
Y Izuno, and
K Kawasaki, and
Y Kaneda, and
Y Mu, and
Y Tsutsumi, and
K W Lem, and
T Mayumi
December 1996,
Biological & pharmaceutical bulletin,
M Maeda, and
Y Izuno, and
K Kawasaki, and
Y Kaneda, and
Y Mu, and
Y Tsutsumi, and
K W Lem, and
T Mayumi
April 1994,
Chemical & pharmaceutical bulletin,
M Maeda, and
Y Izuno, and
K Kawasaki, and
Y Kaneda, and
Y Mu, and
Y Tsutsumi, and
K W Lem, and
T Mayumi
November 2021,
Journal of colloid and interface science,
