BIOMAT Database Logo BIOMAT Database Logo

Prognostic significance of serum p53 antibodies in squamous cell carcinoma of the lung. 1997

T Komiya, and T Hirashima, and M Takada, and N Masuda, and T Yasumitsu, and K Nakagawa, and Y Hosono, and M Kikui, and S Tsuji, and M Fukuoka, and I Kawase
Second Department of Internal Medicine, Osaka Prefectural Habikino Hospital, Osaka, Japan.

BACKGROUND The prognostic significance of serum p53-Abs positivity for non-small cell lung cancer (NSCLC) is still unknown. METHODS To determine the prognostic value of serum p53-Abs status, we determined serum p53-Abs and immunohistochemistry in 140 patients with stage I-IIIA NSCLC. RESULTS p53-Abs were detected in 12.1% of all patients and in 17.6% of those with squamous cell carcinoma (SCC). Neither p53-Abs nor p53 overexpression alone was correlated with survival for all patients. When these factors were combined for SCC, seronegative patients with tumors overexpressing p53 survived significantly longer than did those with p53-Abs or p53-nonexpressing tumors. In multivariate analysis, p53-Abs status and p53 overexpression were independent prognostic factors for SCC (p = 0.0337). CONCLUSIONS These findings suggest that the combination of p53Abs seropositivity and p53 overexpression may be a prognostic factor for SCC.

UI MeSH Term Description Entries
D008175 Lung Neoplasms Tumors or cancer of the LUNG. Cancer of Lung,Lung Cancer,Pulmonary Cancer,Pulmonary Neoplasms,Cancer of the Lung,Neoplasms, Lung,Neoplasms, Pulmonary,Cancer, Lung,Cancer, Pulmonary,Cancers, Lung,Cancers, Pulmonary,Lung Cancers,Lung Neoplasm,Neoplasm, Lung,Neoplasm, Pulmonary,Pulmonary Cancers,Pulmonary Neoplasm
D008297 Male Males
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D002294 Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed) Carcinoma, Epidermoid,Carcinoma, Planocellular,Carcinoma, Squamous,Squamous Cell Carcinoma,Carcinomas, Epidermoid,Carcinomas, Planocellular,Carcinomas, Squamous,Carcinomas, Squamous Cell,Epidermoid Carcinoma,Epidermoid Carcinomas,Planocellular Carcinoma,Planocellular Carcinomas,Squamous Carcinoma,Squamous Carcinomas,Squamous Cell Carcinomas
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000906 Antibodies Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
D016159 Tumor Suppressor Protein p53 Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER. p53 Tumor Suppressor Protein,Cellular Tumor Antigen p53,Oncoprotein p53,TP53 Protein,TRP53 Protein,p53 Antigen,pp53 Phosphoprotein,Phosphoprotein, pp53

Related Publications

T Komiya, and T Hirashima, and M Takada, and N Masuda, and T Yasumitsu, and K Nakagawa, and Y Hosono, and M Kikui, and S Tsuji, and M Fukuoka, and I Kawase
Prognostic significance of p53 gene mutations in squamous cell carcinoma of the lung.
January 1998, Oncology reports,
T Komiya, and T Hirashima, and M Takada, and N Masuda, and T Yasumitsu, and K Nakagawa, and Y Hosono, and M Kikui, and S Tsuji, and M Fukuoka, and I Kawase
Serum p53 antibodies as a prognostic indicator in oral squamous cell carcinoma.
July 2008, Odontology,
T Komiya, and T Hirashima, and M Takada, and N Masuda, and T Yasumitsu, and K Nakagawa, and Y Hosono, and M Kikui, and S Tsuji, and M Fukuoka, and I Kawase
Prognostic significance of serum p53 antibody in patients with esophageal squamous cell carcinoma.
July 2002, Surgery,
T Komiya, and T Hirashima, and M Takada, and N Masuda, and T Yasumitsu, and K Nakagawa, and Y Hosono, and M Kikui, and S Tsuji, and M Fukuoka, and I Kawase
Prognostic significance of serum squamous cell carcinoma antigen in surgically treated lung cancer.
April 2003, Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia,
T Komiya, and T Hirashima, and M Takada, and N Masuda, and T Yasumitsu, and K Nakagawa, and Y Hosono, and M Kikui, and S Tsuji, and M Fukuoka, and I Kawase
Prognostic significance of high serum p53 antibody titers in patients with esophageal squamous cell carcinoma.
October 2018, Esophagus : official journal of the Japan Esophageal Society,
T Komiya, and T Hirashima, and M Takada, and N Masuda, and T Yasumitsu, and K Nakagawa, and Y Hosono, and M Kikui, and S Tsuji, and M Fukuoka, and I Kawase
No prognostic significance of p53 expression in esophageal squamous cell carcinoma.
October 1999, Journal of surgical oncology,
T Komiya, and T Hirashima, and M Takada, and N Masuda, and T Yasumitsu, and K Nakagawa, and Y Hosono, and M Kikui, and S Tsuji, and M Fukuoka, and I Kawase
Prognostic significance of serum p53 antibodies in patients with limited-stage small cell lung cancer.
January 2000, International journal of cancer,
T Komiya, and T Hirashima, and M Takada, and N Masuda, and T Yasumitsu, and K Nakagawa, and Y Hosono, and M Kikui, and S Tsuji, and M Fukuoka, and I Kawase
Changes of serum p53 antibodies and clinical significance of radiotherapy for esophageal squamous cell carcinoma.
July 2008, World journal of gastroenterology,
T Komiya, and T Hirashima, and M Takada, and N Masuda, and T Yasumitsu, and K Nakagawa, and Y Hosono, and M Kikui, and S Tsuji, and M Fukuoka, and I Kawase
Serum anti-p53 antibodies in patients with squamous cell carcinoma of the esophagus.
September 1997, International journal of oncology,
T Komiya, and T Hirashima, and M Takada, and N Masuda, and T Yasumitsu, and K Nakagawa, and Y Hosono, and M Kikui, and S Tsuji, and M Fukuoka, and I Kawase
Significance of p53 expression as a prognostic factor in oesophageal squamous cell carcinoma.
January 1993, Virchows Archiv. A, Pathological anatomy and histopathology,
Copied contents to your clipboard!