-transparent.png){kind=logo}
The effects of whey proteins from bovine milk on melanogenesis in cultured human melanocytes were examined. Among the major protein components of milk whey including beta-lactoglobulin (BLG), alpha-lactalbumin, serum albumin, and IgG, only BLG exhibited the depigmenting effect at a concentration of 1 mg/ml. Also, BLG suppressed the activity of tyrosinase in these cells. Retinol, to which BLG is known to bind, slightly increased the pigmentation of the cells at concentrations in the range of 1-100 nM, and retinoic acid, a metabolite of retinol, exhibited a strong pigmentation-promoting effect within the same concentration range. Treatment of the cells with 1 mg/ml BLG completely abrogated the pigmentation induced by these A vitamins. These results demonstrate a novel biological activity of BLG and suggest that this activity is dependent on its ability to bind retinol.
M Nakajima, and
I Shinoda, and
T Mikogami, and
H Iwamoto, and
S Hashimoto, and
H Miyauchi, and
Y Fukuwatari, and
H Hayasawa
January 1994,
The Journal of endocrinology,
M Nakajima, and
I Shinoda, and
T Mikogami, and
H Iwamoto, and
S Hashimoto, and
H Miyauchi, and
Y Fukuwatari, and
H Hayasawa
December 1997,
Mycoses,
M Nakajima, and
I Shinoda, and
T Mikogami, and
H Iwamoto, and
S Hashimoto, and
H Miyauchi, and
Y Fukuwatari, and
H Hayasawa
October 2003,
Pigment cell research,
M Nakajima, and
I Shinoda, and
T Mikogami, and
H Iwamoto, and
S Hashimoto, and
H Miyauchi, and
Y Fukuwatari, and
H Hayasawa
February 2012,
Phytotherapy research : PTR,
M Nakajima, and
I Shinoda, and
T Mikogami, and
H Iwamoto, and
S Hashimoto, and
H Miyauchi, and
Y Fukuwatari, and
H Hayasawa
August 2020,
Journal of dermatological science,
M Nakajima, and
I Shinoda, and
T Mikogami, and
H Iwamoto, and
S Hashimoto, and
H Miyauchi, and
Y Fukuwatari, and
H Hayasawa
April 1995,
Investigative ophthalmology & visual science,
M Nakajima, and
I Shinoda, and
T Mikogami, and
H Iwamoto, and
S Hashimoto, and
H Miyauchi, and
Y Fukuwatari, and
H Hayasawa
January 2015,
Cutaneous and ocular toxicology,
M Nakajima, and
I Shinoda, and
T Mikogami, and
H Iwamoto, and
S Hashimoto, and
H Miyauchi, and
Y Fukuwatari, and
H Hayasawa
June 2012,
Experimental dermatology,
M Nakajima, and
I Shinoda, and
T Mikogami, and
H Iwamoto, and
S Hashimoto, and
H Miyauchi, and
Y Fukuwatari, and
H Hayasawa
February 2015,
Toxicology in vitro : an international journal published in association with BIBRA,
M Nakajima, and
I Shinoda, and
T Mikogami, and
H Iwamoto, and
S Hashimoto, and
H Miyauchi, and
Y Fukuwatari, and
H Hayasawa
January 2019,
Protein and peptide letters,
