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Characterization of two class I genes from the H2-M region: evidence for a new subfamily. 1998
S R Arepalli, and
E P Jones, and
T K Howcroft, and
I Carlo, and
C Wang, and
K F Lindahl, and
D S Singer, and
S Rudikoff
Laboratory of Genetics and Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
We cloned, sequenced, and mapped two divergent major histocompatibility class Ib genes from BALB/c mice. M9d and M10d both have the potential to encode full-length class I molecules, but transcripts were not readily detectable. M9 is 86% similar to M1 in its nucleotide sequence and maps next to it on YAC clones. M9 is only 64% similar to M10 and 60% to H2-K k. Probes from M10 define a new subfamily of eight class I genes in C3H mice; five cluster directly distal to H2-T1, and three are located between M9-1-7-8 and M6-4-5 in the H2-M region.
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