Biomaterial Database

Tumor-specific immunogenicity induced by chemical modification. 1976

A E Eggers

C57BL/6J spleen cells were immunized in vitro against cells from a syngeneic 3-methylcholanthrene-induced sarcoma, either modified with diazotized sulfanilic acid or left unmodified. The spleen cells were harvested after 5 days and run in a short-term 51Cr-release assay against unmodified tumor cells as targets. The spleen cells sensitized against the modified but not the unmodified tumor cells were cytotoxic for the unmodified tumor cell targets but not for two other syngeneic tumor cell lines or syngeneic spleen cells, thus indicating the production of tumor-specific cytotoxicity.

UI	MeSH Term	Description	Entries
D008214	Lymphocytes	White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.	Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D002478	Cells, Cultured	Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.	Cultured Cells,Cell, Cultured,Cultured Cell
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000951	Antigens, Neoplasm	Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.	Neoplasm Antigens,Tumor Antigen,Tumor Antigens,Antigen, Tumor,Antigens, Tumor
D001391	Azo Compounds	Organic chemicals where aryl or alkyl groups are joined by two nitrogen atoms through a double bond (R-N	Azo Dye,Azo Dyes,Compounds, Azo,Dye, Azo,Dyes, Azo
D001557	Benzenesulfonates	Organic salts and esters of benzenesulfonic acid.
D012513	Sarcoma, Experimental	Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA.	EHS Tumor,Sarcoma, Engelbreth-Holm-Swarm,Sarcoma, Jensen,Experimental Sarcoma,Experimental Sarcomas,Sarcomas, Experimental,Engelbreth-Holm-Swarm Sarcoma,Jensen Sarcoma,Sarcoma, Engelbreth Holm Swarm,Tumor, EHS
D013154	Spleen	An encapsulated lymphatic organ through which venous blood filters.
D013425	Sulfanilic Acids	Aminobenzenesulfonic acids. Organic acids that are used in the manufacture of dyes and organic chemicals and as reagents.	Aminobenzenesulfonic Acids,Anilinesulfonic Acids,Acids, Aminobenzenesulfonic,Acids, Anilinesulfonic,Acids, Sulfanilic