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The cDNAs for two CYP3A genes were isolated from the livers of rats using an RT-PCR approach with CYP3A subfamily-specific primers. Sequence analysis revealed these cDNAs to be identical to CYP3A9, which had previously been isolated from rat brain and nasal epithelium and the recently described CYP3A18. The hepatic expression of both genes was sexually dimorphic. Thus CYP3A18 mRNA levels were 25-fold higher in male livers compared to females, while CYP3A9 showed a reverse pattern with 6-fold higher expression in the liver of females. Exposure of male rats to the female pattern of growth hormone secretion led to an increase in hepatic CYP3A9 mRNA expression and suppressed expression of CYP3A18. These findings indicate that the CYP3A subfamily in rats has both male- and female-specific isoforms which are regulated by growth hormone in a manner similar to some other sexually dimorphic cytochrome P450s.
G R Robertson, and
G C Farrell, and
C Liddle
May 2000,
Biochemical pharmacology,
G R Robertson, and
G C Farrell, and
C Liddle
December 1997,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
G R Robertson, and
G C Farrell, and
C Liddle
November 1995,
Biochemical and biophysical research communications,
G R Robertson, and
G C Farrell, and
C Liddle
April 1991,
Endocrinology,
G R Robertson, and
G C Farrell, and
C Liddle
June 2004,
Growth factors (Chur, Switzerland),
G R Robertson, and
G C Farrell, and
C Liddle
December 2010,
Proceedings of the National Academy of Sciences of the United States of America,
G R Robertson, and
G C Farrell, and
C Liddle
March 2022,
Biology of sex differences,
G R Robertson, and
G C Farrell, and
C Liddle
February 1995,
Endocrinology,
G R Robertson, and
G C Farrell, and
C Liddle
January 2015,
Frontiers in cellular neuroscience,
G R Robertson, and
G C Farrell, and
C Liddle
August 1990,
Molecular endocrinology (Baltimore, Md.),
