Marital separation and divorce are stressful transitions for families. Due to the multitude of stressors imposed, parents and children are at risk for negative emotional, behavioral, and psychological outcomes. Advanced practice nurses are in an excellent position to provide early interventions to separated families that may prevent the need for mental health services that are costly to families and communities. This article discusses the effects of divorce on children and parents and provides guidelines for assessment and intervention with separated families. A description of the Creating Opportunities for Parent Empowerment (COPE) program, a newly developed intervention program for separated parents and their young children, is also included.