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Significant sibling-sibling and within-family correlations of human red blood cell catechol-o-methyl transferase activity have suggested a high degree of genetic control over levels of activity of this catecholamine-related enzyme. However, family studies do not disentangle genetic from environmental similarities as causative of within-family correlations. We therefore undertook a human twin study using the monozygotic-dizygotic comparison method. Twelve pairs of monozygotic twins had an intraclass correlation of 90 in red blood cell catechol-o-methyl transferase activity, and seven pairs of dizygotic twins had an intraclass correlations of 37. Heritability of the enzyme activity was estimated by different methods as between 68-100 per cent.
L Grunhaus, and
R Ebstein, and
R Belmaker, and
S G Sandler, and
W Jonas
January 1976,
Transactions - American Society for Artificial Internal Organs,
L Grunhaus, and
R Ebstein, and
R Belmaker, and
S G Sandler, and
W Jonas
January 1972,
Naunyn-Schmiedeberg's archives of pharmacology,
L Grunhaus, and
R Ebstein, and
R Belmaker, and
S G Sandler, and
W Jonas
August 1976,
The American journal of psychiatry,
L Grunhaus, and
R Ebstein, and
R Belmaker, and
S G Sandler, and
W Jonas
July 1972,
Clinica chimica acta; international journal of clinical chemistry,
L Grunhaus, and
R Ebstein, and
R Belmaker, and
S G Sandler, and
W Jonas
June 2010,
Psychiatria Danubina,
L Grunhaus, and
R Ebstein, and
R Belmaker, and
S G Sandler, and
W Jonas
August 1964,
The Journal of investigative dermatology,
L Grunhaus, and
R Ebstein, and
R Belmaker, and
S G Sandler, and
W Jonas
July 1974,
Psychopharmacology bulletin,
L Grunhaus, and
R Ebstein, and
R Belmaker, and
S G Sandler, and
W Jonas
October 1981,
Research communications in chemical pathology and pharmacology,
L Grunhaus, and
R Ebstein, and
R Belmaker, and
S G Sandler, and
W Jonas
January 1976,
Biochemical pharmacology,
L Grunhaus, and
R Ebstein, and
R Belmaker, and
S G Sandler, and
W Jonas
January 1982,
Human heredity,
