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It was demonstrated that UVB increases synthesis and expression of IL-1 alpha and GM-CSF by keratinocytes. Upregulation of GM-CSF by UVB is reported to be mediated by IL-1 alpha. However, regulation of IL-1 alpha and GM-CSF by UVA is not well-known. The purpose of the present study was to evaluate the effects of UVA on IL-1 alpha and GM-CSF production. Here we used a competitive RT-PCR for measuring cytokine gene expression in an epidermal cell line after UVA irradiation. IL-1 alpha and GM-CSF mRNA did not show any change at 1 h and 6 h following exposure to UVA. After UVA irradiation, however, IL-1 alpha mRNA decreased and GM-CSF mRNA increased at 24 h and the level of GM-CSF in culture supernatant increased at 24 h and 48 h. Addition of antihuman IL-1 alpha neutralizing antibody to UVA irradiated cells did not prevent the increase of GM-CSF mRNA expression. These results suggest that UVA radiation may induce GM-CSF production through an IL-1 alpha independent pathway.
K C Park, and
H C Jung, and
J H Hwang, and
S W Youn, and
J S Ahn, and
S B Park, and
K H Kim, and
J H Chung, and
J I Youn
December 1991,
Journal of leukocyte biology,
K C Park, and
H C Jung, and
J H Hwang, and
S W Youn, and
J S Ahn, and
S B Park, and
K H Kim, and
J H Chung, and
J I Youn
August 2009,
Journal of dental research,
K C Park, and
H C Jung, and
J H Hwang, and
S W Youn, and
J S Ahn, and
S B Park, and
K H Kim, and
J H Chung, and
J I Youn
August 1991,
The Journal of investigative dermatology,
K C Park, and
H C Jung, and
J H Hwang, and
S W Youn, and
J S Ahn, and
S B Park, and
K H Kim, and
J H Chung, and
J I Youn
January 2004,
Inflammation research : official journal of the European Histamine Research Society ... [et al.],
K C Park, and
H C Jung, and
J H Hwang, and
S W Youn, and
J S Ahn, and
S B Park, and
K H Kim, and
J H Chung, and
J I Youn
June 1996,
Melanoma research,
K C Park, and
H C Jung, and
J H Hwang, and
S W Youn, and
J S Ahn, and
S B Park, and
K H Kim, and
J H Chung, and
J I Youn
January 2014,
In vitro cellular & developmental biology. Animal,
K C Park, and
H C Jung, and
J H Hwang, and
S W Youn, and
J S Ahn, and
S B Park, and
K H Kim, and
J H Chung, and
J I Youn
January 2004,
Microbiology and immunology,
K C Park, and
H C Jung, and
J H Hwang, and
S W Youn, and
J S Ahn, and
S B Park, and
K H Kim, and
J H Chung, and
J I Youn
December 1995,
Biochemical and biophysical research communications,
K C Park, and
H C Jung, and
J H Hwang, and
S W Youn, and
J S Ahn, and
S B Park, and
K H Kim, and
J H Chung, and
J I Youn
February 1996,
The Journal of clinical investigation,
K C Park, and
H C Jung, and
J H Hwang, and
S W Youn, and
J S Ahn, and
S B Park, and
K H Kim, and
J H Chung, and
J I Youn
January 1993,
Journal of biological regulators and homeostatic agents,
