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We evaluated the incidence of bone marrow involvement in 121 patients with non-Hodgkin's lymphoma who were seen prior to the institution of definitive therapy. Involvement of the marrow was found to be dependent on both histologic type and the extent of extramedullary disease. It was observed most frequently in patients with poorly differentiated lymphocytic lymphoma (60%), but was not observed in 36 patients of all histologic types whose clinical evaluation and/or laparotomy revealed disease in stage I or II. Among 56 patients with poorly differentiated lymphocytic lymphoma in stage III or IV exclusive of marrow involvement, disease was observed in the marrow in 40 patients, or 71%. These observations, together with the results of previously reported therapeutic trials, suggest that staging laparotomy and total nodal radiotherapy alone may be of limited value in patients with poorly differentiated lymphocytic lymphoma when clinical evidence of stage III or IV disease is present.
R S Stein, and
J E Ultmann, and
G E Byrne, and
E M Moran, and
H M Golomb, and
N Oetzel
April 1983,
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
R S Stein, and
J E Ultmann, and
G E Byrne, and
E M Moran, and
H M Golomb, and
N Oetzel
February 1989,
Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association,
R S Stein, and
J E Ultmann, and
G E Byrne, and
E M Moran, and
H M Golomb, and
N Oetzel
December 1994,
East African medical journal,
R S Stein, and
J E Ultmann, and
G E Byrne, and
E M Moran, and
H M Golomb, and
N Oetzel
January 1989,
Medical and pediatric oncology,
R S Stein, and
J E Ultmann, and
G E Byrne, and
E M Moran, and
H M Golomb, and
N Oetzel
January 1978,
Bibliotheca haematologica,
R S Stein, and
J E Ultmann, and
G E Byrne, and
E M Moran, and
H M Golomb, and
N Oetzel
November 2000,
Zhonghua zhong liu za zhi [Chinese journal of oncology],
R S Stein, and
J E Ultmann, and
G E Byrne, and
E M Moran, and
H M Golomb, and
N Oetzel
January 1989,
Hematologic pathology,
R S Stein, and
J E Ultmann, and
G E Byrne, and
E M Moran, and
H M Golomb, and
N Oetzel
June 1987,
The Indian journal of medical research,
R S Stein, and
J E Ultmann, and
G E Byrne, and
E M Moran, and
H M Golomb, and
N Oetzel
February 1995,
Bone marrow transplantation,
R S Stein, and
J E Ultmann, and
G E Byrne, and
E M Moran, and
H M Golomb, and
N Oetzel
June 1990,
Hematology/oncology clinics of North America,
