BIOMAT Database Logo BIOMAT Database Logo

Inhibitory effect of 1alpha-hydroxyvitamin D3 on N-methyl-N'-nitro-N-nitrosoguanidine-induced gastrointestinal carcinogenesis in Wistar rats. 1998

A Kawaura, and N Tanida, and M Nishikawa, and I Yamamoto, and K Sawada, and T Tsujiai, and K B Kang, and K Izumi
Second Department of Pathology, School of Medicine, The University of Tokushima, Japan.

The effect of 1alpha-hydroxyvitamin D3 (1alpha(OH)D3) on gastrointestinal carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was investigated in male Wistar rats. After oral treatment with 0.01% MNNG for 24 weeks, rats were given 0.04 microg of 1alpha(OH)D3 or its vehicle by gastric intubation three times a week for 24 weeks. The incidence of gastrointestinal tumors was 16/30 (53%) in rats treated with MNNG alone, 16/30 (53%) in those treated with MNNG plus vehicle and 8/30 (27%, P < 0.05) in those treated with MNNG plus 1alpha(OH)D3. The number of tumors per rat in the group treated with MNNG plus 1alpha(OH)D3 was half those in the control groups (P < 0.05). Results indicated that a non-hypercalcemic dose of 1alpha(OH)D3 had an inhibitory effect on MNNG-induced duodeno-intestinal carcinogenesis.

UI MeSH Term Description Entries
D008297 Male Males
D008769 Methylnitronitrosoguanidine A nitrosoguanidine derivative with potent mutagenic and carcinogenic properties. Methylnitrosonitroguanidine,Nitrosomethylnitroguanidine,Nitrosonitromethylguanidine,MNNG,N-Methyl-N'-nitro-N-nitrosoguanidine,N Methyl N' nitro N nitrosoguanidine
D005770 Gastrointestinal Neoplasms Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL. Gastrointestinal Cancer,Cancer of Gastrointestinal Tract,Cancer of the Gastrointestinal Tract,Neoplasms, Gastrointestinal,Cancer, Gastrointestinal,Cancers, Gastrointestinal,Gastrointestinal Cancers,Gastrointestinal Neoplasm,Gastrointestinal Tract Cancer,Gastrointestinal Tract Cancers,Neoplasm, Gastrointestinal
D006887 Hydroxycholecalciferols Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3. Hydroxyvitamins D,Hydroxycholecalciferol
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D017208 Rats, Wistar A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain. Wistar Rat,Rat, Wistar,Wistar Rats
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

A Kawaura, and N Tanida, and M Nishikawa, and I Yamamoto, and K Sawada, and T Tsujiai, and K B Kang, and K Izumi
Effect of 5-fluorouracil on gastrointestinal carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats.
January 1999, Digestive diseases and sciences,
A Kawaura, and N Tanida, and M Nishikawa, and I Yamamoto, and K Sawada, and T Tsujiai, and K B Kang, and K Izumi
Enhancement by propranolol of the inhibitory effect of tetragastrin on gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
January 1987, Cancer research,
A Kawaura, and N Tanida, and M Nishikawa, and I Yamamoto, and K Sawada, and T Tsujiai, and K B Kang, and K Izumi
Effect of cimetidine on inhibition by tetragastrin of carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
March 1988, Cancer research,
A Kawaura, and N Tanida, and M Nishikawa, and I Yamamoto, and K Sawada, and T Tsujiai, and K B Kang, and K Izumi
Effect of cyclosporine on carcinogenesis induced in rats by N-methyl-N'-nitro-N-nitrosoguanidine.
September 1984, The Journal of surgical research,
A Kawaura, and N Tanida, and M Nishikawa, and I Yamamoto, and K Sawada, and T Tsujiai, and K B Kang, and K Izumi
Enhancement by thyroxine of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
September 1993, British journal of cancer,
A Kawaura, and N Tanida, and M Nishikawa, and I Yamamoto, and K Sawada, and T Tsujiai, and K B Kang, and K Izumi
Promotion by ethanol of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
May 1989, British journal of cancer,
A Kawaura, and N Tanida, and M Nishikawa, and I Yamamoto, and K Sawada, and T Tsujiai, and K B Kang, and K Izumi
Promotion by vagotomy of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
January 1985, Cancer research,
A Kawaura, and N Tanida, and M Nishikawa, and I Yamamoto, and K Sawada, and T Tsujiai, and K B Kang, and K Izumi
Enhancement by aminoguanidine of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
January 1997, Oncology reports,
A Kawaura, and N Tanida, and M Nishikawa, and I Yamamoto, and K Sawada, and T Tsujiai, and K B Kang, and K Izumi
Promotion by neurotensin of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
February 1989, Cancer research,
A Kawaura, and N Tanida, and M Nishikawa, and I Yamamoto, and K Sawada, and T Tsujiai, and K B Kang, and K Izumi
Promotion by bombesin of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
October 1989, Cancer research,
Copied contents to your clipboard!