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A practical method for monitoring serum theophylline concentrations has been used to investigate intravenous aminophylline dosage requirements. Initial serum theophylline concentrations were found to vary widely and correlate poorly with drug history. Aminophylline loading doses determined from these values more frequently resulted in drug concentrations in the therapeutic range (10 mug to 20 mug/ml) than when therapy was given without knowledge of serum theophylline concentrations. Continuous intravenous aminophylline therapy administered in a standardized dosage (0.9 mg/kg/hr in adults and 1.0 mg/kg/hr in children) produced variable and often excessive serum concentrations. This resulted from variable drug clearance rates, which in adults averaged 0.64 +/- 0.38 ml/kg/min (mean +/- SD), only half that previously reported. These observations suggest that it is not possible to achieve optimal therapeutic aminophylline dosage without monitoring serum theophylline concentrations.
M W Weinberger, and
R A Matthay, and
E J Ginchansky, and
C A Chidsey, and
T L Petty
July 1980,
American journal of hospital pharmacy,
M W Weinberger, and
R A Matthay, and
E J Ginchansky, and
C A Chidsey, and
T L Petty
December 1982,
Annals of allergy,
M W Weinberger, and
R A Matthay, and
E J Ginchansky, and
C A Chidsey, and
T L Petty
March 1984,
Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
M W Weinberger, and
R A Matthay, and
E J Ginchansky, and
C A Chidsey, and
T L Petty
May 1985,
Journal of pharmaceutical sciences,
M W Weinberger, and
R A Matthay, and
E J Ginchansky, and
C A Chidsey, and
T L Petty
April 1982,
Drug intelligence & clinical pharmacy,
M W Weinberger, and
R A Matthay, and
E J Ginchansky, and
C A Chidsey, and
T L Petty
March 1984,
British medical journal (Clinical research ed.),
M W Weinberger, and
R A Matthay, and
E J Ginchansky, and
C A Chidsey, and
T L Petty
March 1986,
Medicina clinica,
M W Weinberger, and
R A Matthay, and
E J Ginchansky, and
C A Chidsey, and
T L Petty
November 1980,
European journal of clinical pharmacology,
M W Weinberger, and
R A Matthay, and
E J Ginchansky, and
C A Chidsey, and
T L Petty
October 1984,
British journal of clinical pharmacology,
M W Weinberger, and
R A Matthay, and
E J Ginchansky, and
C A Chidsey, and
T L Petty
July 1978,
The American review of respiratory disease,
