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Effects of amphetamine on the development of Moloney sarcoma virus-induced tumors in mice. 1998
M Freire-Garabal, and
M J Nuñez-Iglesias, and
M Rey-Méndez, and
M D Pereiro-Raposo, and
P Riveiro, and
J C Fernández-Rial, and
C Losada, and
M Gandoy, and
J M Mayán
Department of Pharmacology, School of Pharmacy, University of Santiago de Compostela, Campus Sur, Santiago de Compostela, 15706, Spain.
Experiments were conducted to evaluate the effects of amphetamine (0. 4 mg/kg) on the development of autochthonous tumors induced by the Moloney sarcoma virus (MSV) in Balb/c female mice. Enhancement of MSV-induced tumor incidence and tumor growth was observed, together with a delay in the usual prompt regression of the tumors, when mice were daily injected with amphetamine for 3 days after MSV-inoculation. However, no effects of amphetamine on tumor development were observed when it was administered during the 3 days before tumor inoculation.
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