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Human papillomavirus DNA in multicentric vulvar intraepithelial neoplasia. 1998

M van Beurden, and F W ten Kate, and S P Tjong-A-Hung, and A J de Craen, and N van der Vange, and F B Lammes, and J ter Schegget
Department of Obstetrics and Gynecology, Academic Medical Centre, Amsterdam, The Netherlands.

Human papillomavirus (HPV) DNA in vulvar intraepithelial neoplasia (VIN) is associated with multifocality of VIN III and with multicentricity of other neoplastic squamous lesions in the cervix and vagina. The aim of this study was to establish the prevalence and type of HPV DNA in the lesions of vaginal intraepithelial neoplasia (VaIN) and cervical intraepithelial neoplasia (CIN) in patients with VIN III using the polymerase chain reaction (PCR). HPV DNA detection and histologic analysis were performed on alternating sections of paraffin-embedded biopsies of concomitant CIN and VaIN in 27 patients with VIN III. PCR was performed with consensus primers and HPV typing was performed by direct sequencing of the PCR amplimers. HPV DNA was detected in all VIN III lesions (93% contained HPV-16 DNA); in 96% of the CIN lesions (73% contained HPV-16 DNA); and in all VaIN lesions (75% contained HPV-16 DNA). The HPV type was not the same in 22% of the different lesions of VIN, CIN, and VaIN, even if the biopsies were taken at the same time.

UI MeSH Term Description Entries
D002583 Uterine Cervical Neoplasms Tumors or cancer of the UTERINE CERVIX. Cancer of Cervix,Cancer of the Cervix,Cancer of the Uterine Cervix,Cervical Cancer,Cervical Neoplasms,Cervix Cancer,Cervix Neoplasms,Neoplasms, Cervical,Neoplasms, Cervix,Uterine Cervical Cancer,Cancer, Cervical,Cancer, Cervix,Cancer, Uterine Cervical,Cervical Cancer, Uterine,Cervical Cancers,Cervical Neoplasm,Cervical Neoplasm, Uterine,Cervix Neoplasm,Neoplasm, Cervix,Neoplasm, Uterine Cervical,Uterine Cervical Cancers,Uterine Cervical Neoplasm
D004279 DNA, Viral Deoxyribonucleic acid that makes up the genetic material of viruses. Viral DNA
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D014625 Vaginal Neoplasms Tumors or cancer of the VAGINA. Cancer of Vagina,Vaginal Cancer,Cancer of the Vagina,Neoplasms, Vaginal,Vagina Cancer,Vagina Neoplasms,Cancer, Vagina,Cancer, Vaginal,Cancers, Vagina,Cancers, Vaginal,Neoplasm, Vagina,Neoplasm, Vaginal,Neoplasms, Vagina,Vagina Cancers,Vagina Neoplasm,Vaginal Cancers,Vaginal Neoplasm
D014846 Vulvar Neoplasms Tumors or cancer of the VULVA. Cancer of Vulva,Vulvar Cancer,Cancer of the Vulva,Neoplasms, Vulvar,Vulva Cancer,Vulva Neoplasms,Cancer, Vulva,Cancer, Vulvar,Cancers, Vulva,Cancers, Vulvar,Neoplasm, Vulva,Neoplasm, Vulvar,Neoplasms, Vulva,Vulva Cancers,Vulva Neoplasm,Vulvar Cancers,Vulvar Neoplasm
D027383 Papillomaviridae A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.

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